Reactome | NEDD4 [cytosol]

NEDD4 [cytosol]

Stable Identifier

R-HSA-975992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase NEDD4, NEDD4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46934 NEDD4

Gene Names

NEDD4, KIAA0093, NEDD4-1, RPF1, PIG53

Chain

chain:1-1319, initiator methionine:1

Reference Genes

BioGPS Gene:4734 NEDD4

COSMIC (genes):NEDD4 NEDD4

COSMIC (genes):RPF1 NEDD4

CTD Gene:4734 NEDD4

dbSNP Gene:4734 NEDD4

ENSEMBL:ENSG00000069869 NEDD4

HGNC:7727 NEDD4

KEGG:hsa:4734 NEDD4

Monarch:4734 NEDD4

NCBI Gene:4734 NEDD4

OMIM:602278 NEDD4

UCSC:P46934 NEDD4

Reference Transcript

Participates

as a component of

as an input of

as a member of

NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)

as a candidate of

Inferred To

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

Nedd4 [cytosol] (Drosophila melanogaster)

Nedd4 [cytosol] (Mus musculus)

Nedd4 [cytosol] (Rattus norvegicus)

NEDD4 [cytosol] (Bos taurus)

NEDD4 [cytosol] (Caenorhabditis elegans)

NEDD4 [cytosol] (Canis familiaris)

NEDD4 [cytosol] (Gallus gallus)

NEDD4 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001271269.1, NP_006145.2, NP_001271268.1, NP_940682.2, NP_001316141.1, NP_001271267.1

OpenTargets

ENSG00000069869

ENSEMBL

ENSG00000069869, ENSP00000410613, ENST00000506154, ENST00000508342, ENST00000338963, ENSP00000345530, ENST00000435532, ENSP00000424827, ENSP00000422705

GeneCards

NEDD4

HPA

ENSG00000069869-NEDD4

PRO

P46934

Pharos - Targets

P46934

GlyGen

P46934

HMDB Protein

HMDBP09283

PDB

2KQ0, 4BBN, 2XBB, 5AHT, 4N7H, 2M3O, 4N7F, 4BE8, 2KPZ, 3B7Y, 2XBF, 5C7J, 5C91

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZD6 TMG4			0.815	5
UniProt:P51168 SCNN1B	1	SCNN1B [plasma membrane] (R-HSA-2671900)	0.806	7
UniProt:Q96B67 ARRD3			0.793	5
UniProt:Q99732 LITAF			0.788	7
UniProt:Q9Y3C5 RNF11			0.786	7
UniProt:Q15884 EREP1			0.688	5
UniProt:O15165 LRAD4			0.688	5
UniProt:P37088 SCNN1A	2	Ub-SCNN1A [plasma membrane] (R-HSA-2684930) SCNN1A [plasma membrane] (R-HSA-2671922)	0.683	3
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.672	26
UniProt:Q8N5I2 ARRD1			0.643	4
UniProt:Q9GZQ8 MAP1LC3B	4	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [extracellular exosome] (R-HSA-9959986)	0.623	2
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.623	2
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.623	2
UniProt:Q96PN7 TREF1			0.623	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.591	4
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.59	2
UniProt:Q16655 MLANA	1	MLANA [melanosome membrane] (R-HSA-9825829)	0.59	2
UniProt:Q96PG2 M4A10			0.59	2
UniProt:Q8TB68 PRR7			0.59	2
UniProt:Q9NW97 TMM51			0.59	3
UniProt:Q8N4L2 PP4P2			0.59	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q13571 LAPM5			0.547	2
UniProt:P28282 UL56			0.544	8
UniProt:Q5XX06 VP40			0.544	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	2
UniProt:Q8WVE6 TM171			0.527	3
UniProt:P81408 EREP3			0.527	4
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.525	6
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.525	6
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.525	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	9
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.463	3

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