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RNF123 [cytosol]
Stable Identifier
R-HSA-975996
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF123, RN123_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP19 deubiquitinates RNF123 (Homo sapiens)
USP19:RNF123 [cytosol] (Homo sapiens)
RNF123 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5XPI4 RNF123
Gene Names
RNF123, KPC1, FP1477
Chain
initiator methionine:, chain:2-1314
Reference Genes
BioGPS Gene:63891 RNF123
COSMIC (genes):RNF123 RNF123
CTD Gene:63891 RNF123
dbSNP Gene:63891 RNF123
ENSEMBL:ENSG00000164068 RNF123
ENSEMBL_homo_sapiens_GENE:ENSG00000164068.16 RNF123
HGNC:21148 RNF123
KEGG Gene (Homo sapiens):63891 RNF123
Monarch:63891 RNF123
NCBI Gene:63891 RNF123
OMIM:614472 RNF123
UCSC:Q5XPI4 RNF123
Reference Transcript
RefSeq:XM_017007018.1 RNF123
RefSeq:XM_006713285.1 RNF123
RefSeq:NM_022064.4 RNF123
RefSeq:XM_011533995.1 RNF123
Other Identifiers
11741002_a_at
11744979_a_at
16940766
221063_PM_x_at
221063_x_at
224186_PM_s_at
224186_s_at
2398408
2622241
2622245
2622246
2622247
2622249
2622250
2622251
2622252
2622253
2622254
2622255
2622256
2622258
2622259
2622261
2622262
2622263
2622265
2622266
2622268
2622269
2622270
2622271
2622273
2622275
2622276
2622278
2622280
2622282
2622285
2622286
2622288
2622289
2622291
2622292
2622293
2622294
2622299
2622300
2622302
2622303
2622304
2622305
2622306
2622307
2622308
2622309
54629_at
63891
8079796
A_14_P131061
A_14_P133902
GE82644
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005635
GO:0005737
GO:0005829
GO:0006511
GO:0016567
GO:0016740
GO:0030163
GO:0031965
GO:0036211
GO:0043226
GO:0046872
GO:0051603
GO:0051604
GO:0061630
GO:0140096
HMNXSV003013112
ILMN_1663605
PH_hs_0030702
TC03000298.hg
g11545772_3p_s_at
Participates
as a component of
USP19:RNF123 [cytosol] (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-RNF123 [cytosol]
Inferred To
RNF123 [cytosol]
(Bos taurus)
RNF123 [cytosol]
(Canis familiaris)
RNF123 [cytosol]
(Dictyostelium discoideum)
RNF123 [cytosol]
(Gallus gallus)
RNF123 [cytosol]
(Mus musculus)
RNF123 [cytosol]
(Rattus norvegicus)
RNF123 [cytosol]
(Sus scrofa)
Kpc1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011532297.1
,
NP_071347.2
,
XP_006713348.1
,
XP_016862507.1
OpenTargets
ENSG00000164068
GeneCards
Q5XPI4
HPA
ENSG00000164068-RNF123
Ensembl
ENSP00000328287
,
ENSG00000164068
,
ENST00000327697
PRO
Q5XPI4
Pharos - Targets
Q5XPI4
PDB
2MA6
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.553
2
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