Reactome | RBCK1 [cytosol]

RBCK1 [cytosol]

Stable Identifier

R-HSA-976018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RanBP-type and C3HC4-type zinc finger-containing protein 1, UB7I3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BYM8 RBCK1

Gene Names

RBCK1, C20orf18, RNF54, UBCE7IP3, XAP3, XAP4

Chain

chain:1-510

Reference Genes

BioGPS Gene:10616 RBCK1

COSMIC (genes):RBCK1 RBCK1

CTD Gene:10616 RBCK1

dbSNP Gene:10616 RBCK1

ENSEMBL:ENSG00000125826 RBCK1

HGNC:15864 RBCK1

KEGG:hsa:10616 RBCK1

Monarch:10616 RBCK1

NCBI Gene:10616 RBCK1

OMIM:610924 RBCK1

UCSC:Q9BYM8 RBCK1

Reference Transcript

Other Identifiers

10616

11735723_s_at

11752690_a_at

11756449_x_at

11761110_x_at

16910618

207713_PM_s_at

207713_s_at

221827_PM_at

221827_at

229920_PM_at

229920_at

32202_at

32203_at

3873184

3873186

3873187

3873188

3873189

3873190

3873191

3873192

3873195

3873199

3873200

3873201

3873202

3873203

3873204

3873205

3873206

3873207

3873208

3873209

3873210

3873211

3873212

3873213

3873214

3873215

3873216

3873217

3873218

3873219

3873220

3873221

3873222

3873223

3873224

3873225

3873230

3873232

49302_at

50146_at

8060353

A_14_P129653

A_23_P166051

A_33_P3238315

A_33_P3238323

GE549071

GE62827

GE85821

GO:0000209

GO:0002376

GO:0003713

GO:0003824

GO:0004842

GO:0005515

GO:0005829

GO:0006355

GO:0009893

GO:0016567

GO:0016740

GO:0030163

GO:0032088

GO:0042742

GO:0042802

GO:0043065

GO:0043123

GO:0043130

GO:0043161

GO:0045893

GO:0046872

GO:0050852

GO:0051092

GO:0060090

GO:0060546

GO:0071797

GO:0097039

GO:0098542

GO:0098772

GO:0140096

GO:0140110

GO:1901224

GO:1990757

GO:2001238

HMNXSV003008003

HMNXSV003033231

HMNXSV003036502

Hs.247280.3.A1_3p_a_at

Hs.247280.3.A1_3p_x_at

Hs.29546.0.S1_3p_at

ILMN_1751330

ILMN_2406313

PH_hs_0013094

PH_hs_0041038

TC20000010.hg

g5454167_3p_a_at

Participates

as a component of

LUBAC [cytosol] (Homo sapiens)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

C20orf18 [cytosol] (Bos taurus)

Ghost homologue of RBCK1 [cytosol] (Gallus gallus)

RBCK1 [cytosol] (Caenorhabditis elegans)

RBCK1 [cytosol] (Canis familiaris)

RBCK1 [cytosol] (Mus musculus)

RBCK1 [cytosol] (Rattus norvegicus)

RBCK1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_112506.2, NP_006453.1

OpenTargets

ENSG00000125826

ENSEMBL

ENSP00000348632, ENST00000353660, ENSP00000254960, ENST00000382181, ENSP00000371616, ENST00000356286

IntEnz

2.3.2.31

HPA

ENSG00000125826-RBCK1

PRO

Q9BYM8

Pharos - Targets

Q9BYM8

Orphanet

RBCK1

PDB

8EAZ, 4DBG, 7YUI, 7V8E, 2CRC, 2LGY, 7YUJ, 8BVL

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.868	28
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.858	9
UniProt:O14933 UBE2L6	2	UBE2L6 [cytosol] (R-HSA-936014) UBE2L6 [nucleoplasm] (R-HSA-5653666)	0.781	7
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.725	6
UniProt:P68036 UBE2L3	4	Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201) UBE2L3 [cytosol] (R-HSA-947631) UBE2L3 [nucleoplasm] (R-HSA-8852056) Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226)	0.666	4
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.592	2
UniProt:Q9JLY0 Socs6	2	Socs6 [cytosol] (R-MMU-1469973) Socs6 [cytosol] (R-MMU-1469969)	0.581	5
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:Q9BU61 NDUFAF3	1	NDUFAF3 [mitochondrial inner membrane] (R-HSA-5689126)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2

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