Reactome | TRIM63 [cytosol]

TRIM63 [cytosol]

Stable Identifier

R-HSA-976020

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase TRIM63, TRI63_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P26641 EEF1G

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External Reference Information

External Reference

UniProt:Q969Q1 TRIM63

Gene Names

TRIM63, IRF, MURF1, RNF28, SMRZ

Chain

chain:1-353

Reference Genes

BioGPS Gene:84676 TRIM63

COSMIC (genes):TRIM63 TRIM63

CTD Gene:84676 TRIM63

dbSNP Gene:84676 TRIM63

ENSEMBL:ENSG00000158022 TRIM63

ENSEMBL_homo_sapiens_GENE:ENSG00000158022.7 TRIM63

HGNC:16007 TRIM63

KEGG Gene (Homo sapiens):84676 TRIM63

Monarch:84676 TRIM63

NCBI Gene:84676 TRIM63

OMIM:606131 TRIM63

UCSC:Q969Q1 TRIM63

Reference Transcript

RefSeq:NM_032588.3 TRIM63

Other Identifiers

11731527_s_at

11731528_x_at

11749907_a_at

16683771

236972_PM_at

236972_at

2402537

2402538

2402539

2402541

2402542

2402543

2402545

2402548

2402549

2402550

2402551

77301_at

7913907

84676

GE546674

GO:0003012

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0006936

GO:0007165

GO:0008092

GO:0008270

GO:0010614

GO:0014732

GO:0014878

GO:0016567

GO:0016740

GO:0023052

GO:0030018

GO:0031430

GO:0031432

GO:0036211

GO:0043226

GO:0043292

GO:0046872

GO:0051384

GO:0061630

GO:0070555

GO:0140096

HMNXSV003009208

Hs.157119.0.A1_3p_at

ILMN_1702489

PH_hs_0014385

TC01002386.hg

Participates

as an output of

TRIM63 gene expression is stimulated by FOXO1 and FOXO3 (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

trim63b [cytosol] (Danio rerio)

TRIM63 [cytosol] (Bos taurus)

TRIM63 [cytosol] (Caenorhabditis elegans)

TRIM63 [cytosol] (Canis familiaris)

TRIM63 [cytosol] (Mus musculus)

TRIM63 [cytosol] (Rattus norvegicus)

TRIM63 [cytosol] (Sus scrofa)

trim63 [cytosol] (Xenopus tropicalis)

Homologues of TRIM63 [cytosol] (Danio rerio)

trim55a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_115977.2

OpenTargets

ENSG00000158022

IntEnz

2.3.2.27

GeneCards

Q969Q1

HPA

ENSG00000158022-TRIM63

Ensembl

ENST00000374272, ENSP00000363390, ENSG00000158022

PRO

Q969Q1

Pharos - Targets

Q969Q1

HMDB Protein

HMDBP09318

PDB

3DDT, 2D8U, 4M3L

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q8WZ42 TTN	2	TTN [extracellular region] (R-HSA-350729) TTN [cytosol] (R-HSA-350726)	0.553	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.553	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.537	3
UniProt:Q9NP98 MYOZ1			0.508	2
UniProt:Q92995 USP13	2	USP13 [nucleoplasm] (R-HSA-6781924) USP13 [cytosol] (R-HSA-6781893)	0.508	2
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.508	2
UniProt:Q8IXM3 MRPL41	1	MRPL41 [mitochondrial inner membrane] (R-HSA-5368230)	0.508	2
UniProt:Q96RP9 GFM1	1	GFM1 [mitochondrial matrix] (R-HSA-5389859)	0.508	2
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.508	2

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