Reactome | FBXW11 [cytosol]

FBXW11 [cytosol]

Stable Identifier

R-HSA-976035

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box/WD repeat-containing protein 11, FBW1B_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
        
        Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
        
        p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Homo sapiens)
        
        (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] (Homo sapiens)
        
        CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXW11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UKB1 FBXW11

Gene Names

FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696

Chain

chain:1-542

Reference Genes

BioGPS Gene:23291 FBXW11

COSMIC (genes):FBXW11 FBXW11

CTD Gene:23291 FBXW11

dbSNP Gene:23291 FBXW11

ENSEMBL:ENSG00000072803 FBXW11

ENSEMBL:ENSG00000072803.18 FBXW11

HGNC:13607 FBXW11

KEGG Gene (Homo sapiens):23291 FBXW11

Monarch:23291 FBXW11

NCBI Gene:23291 FBXW11

OMIM:605651 FBXW11

UCSC:Q9UKB1 FBXW11

Reference Transcript

Other Identifiers

11739227_a_at

11739228_x_at

11739229_a_at

11758649_s_at

17002753

209455_PM_at

209455_at

209456_PM_s_at

209456_s_at

23291

2886984

2886985

2886986

2886991

2886992

2886993

2886994

2886996

2886999

2887000

2887001

2887003

2887006

2887007

2887008

2887014

2887015

2887022

2887038

2887039

2887040

2887041

32854_at

3928821

3928831

8115765

A_23_P214046

A_24_P257539

GE83659

GO:0000132

GO:0000151

GO:0000209

GO:0000278

GO:0000776

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005875

GO:0005881

GO:0006351

GO:0006355

GO:0006470

GO:0007010

GO:0007018

GO:0007049

GO:0007097

GO:0007163

GO:0007281

GO:0008090

GO:0008092

GO:0016055

GO:0016567

GO:0016740

GO:0019005

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0031023

GO:0031146

GO:0031648

GO:0036211

GO:0042753

GO:0043005

GO:0043025

GO:0043161

GO:0043226

GO:0045862

GO:0045892

GO:0045893

GO:0046983

GO:0047496

GO:0048511

GO:0048854

GO:0048856

GO:0051010

GO:0070840

GO:0140096

GO:1904115

HMNXSV003042412

Hs.21229.0.A3_3p_at

ILMN_1735655

ILMN_1766983

ILMN_2394571

ILMN_2394576

PH_hs_0041152

TC05002058.hg

g7209812_3p_a_at

Participates

as a member of

as a component of

CUL1:FBXW11:SKP1 [cytosol] (Homo sapiens)

Inferred To

Lis-1 [cytosol] (Drosophila melanogaster)

agtA [cytosol] (Dictyostelium discoideum)

wdr-5.3 [cytosol] (Caenorhabditis elegans)

lis-1 [cytosol] (Caenorhabditis elegans)

Fbxw11 [cytosol] (Mus musculus)

Fbxw11 [cytosol] (Rattus norvegicus)

Homologues of FBXW11 [cytosol] (Caenorhabditis elegans)

Homologues of FBXW11 [cytosol] (Danio rerio)

Homologues of FBXW11 [cytosol] (Dictyostelium discoideum)

pafah1b1b [cytosol] (Danio rerio)

PAC1 [cytosol] (Saccharomyces cerevisiae)

pafah1b1 [cytosol] (Xenopus tropicalis)

pafah1b1a [cytosol] (Danio rerio)

FBXW11 [cytosol] (Bos taurus)

FBXW11 [cytosol] (Canis familiaris)

FBXW11 [cytosol] (Dictyostelium discoideum)

FBXW11 [cytosol] (Gallus gallus)

FBXW11 [cytosol] (Schizosaccharomyces pombe)

wdr-5.2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_387449.2, NP_036432.2, NP_387448.2

OpenTargets

ENSG00000072803

HPA

ENSG00000072803-FBXW11

GeneCards

Q9UKB1

Ensembl

ENSG00000072803, ENSP00000377391, ENST00000393802, ENST00000296933, ENST00000265094, ENSP00000296933, ENSP00000265094

PRO

Q9UKB1

Pharos - Targets

Q9UKB1

Orphanet

28924

PDB

6WNX

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.931	11
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.924	13
UniProt:P30304 CDC25A	6	PolyUb-CDC25A [cytosol] (R-HSA-6782810) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.763	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.723	4
UniProt:O00418 EEF2K	2	p-S366-EEF2K [cytosol] (R-HSA-165755) EEF2K [cytosol] (R-HSA-165745)	0.643	3
UniProt:Q13127 REST	1	REST [nucleoplasm] (R-HSA-480506)	0.623	3
UniProt:P30291 WEE1	3	p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) WEE1 [nucleoplasm] (R-HSA-69253)	0.604	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.589	3
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846)	0.564	2
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.558	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	4
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.499	4
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.462	4

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