Reactome | WWP1 [cytosol]

WWP1 [cytosol]

Stable Identifier

R-HSA-976037

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD4-like E3 ubiquitin-protein ligase WWP1, WWP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3

Expand all

External Reference Information

External Reference

UniProt:Q9H0M0 WWP1

Gene Names

WWP1

Chain

chain:1-922

Reference Genes

BioGPS Gene:11059 WWP1

COSMIC (genes):WWP1 WWP1

CTD Gene:11059 WWP1

dbSNP Gene:11059 WWP1

ENSEMBL:ENSG00000123124 WWP1

ENSEMBL_homo_sapiens_GENE:ENSG00000123124.14 WWP1

HGNC:17004 WWP1

KEGG Gene (Homo sapiens):11059 WWP1

Monarch:11059 WWP1

NCBI Gene:11059 WWP1

OMIM:602307 WWP1

UCSC:Q9H0M0 WWP1

Reference Transcript

Other Identifiers

11059

11726319_at

11758956_at

11758957_x_at

17070514

212637_PM_s_at

212637_s_at

212638_PM_s_at

212638_s_at

2633223

2633226

2633227

2633228

2633229

2633231

2633232

2633235

2633237

3105789

3105790

3105791

3105797

3105800

3105804

3105805

3105811

3105813

3105814

3105815

3105816

3105820

3105821

3105825

3105828

3105829

3105830

3105832

3105835

3105836

3105838

3105843

3105845

3105846

3105848

3105849

3105850

3105851

3105855

3105856

3105857

3105858

3105859

3105860

3105861

3105862

3105863

3105864

3105865

40902_at

783_at

784_g_at

8147156

A_14_P108444

A_14_P126779

A_23_P146990

GE79116

GE85861

GO:0000151

GO:0003824

GO:0004842

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006511

GO:0007165

GO:0007417

GO:0016020

GO:0016567

GO:0016740

GO:0023052

GO:0030163

GO:0034220

GO:0036211

GO:0043161

GO:0043226

GO:0045892

GO:0046718

GO:0048856

GO:0055085

GO:0061630

GO:0070062

GO:0140096

HMNXSV003041033

Hs.324275.0.S1_3p_s_at

Hs.324275.0.S2_3p_a_at

ILMN_1804328

ILMN_2215370

TC08000538.hg

U96113_at

Participates

as a member of

as an output of

Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)

as an input of

RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)

as a component of

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

wwp1 [cytosol] (Xenopus tropicalis)

Homologues of WWP1 [cytosol] (Dictyostelium discoideum)

Su(dx) [cytosol] (Drosophila melanogaster)

WWP1 [cytosol] (Bos taurus)

WWP1 [cytosol] (Canis familiaris)

WWP1 [cytosol] (Dictyostelium discoideum)

WWP1 [cytosol] (Gallus gallus)

WWP1 [cytosol] (Plasmodium falciparum)

WWP1 [cytosol] (Sus scrofa)

Wwp1 [cytosol] (Mus musculus)

Wwp1 [cytosol] (Rattus norvegicus)

wwp-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005250817.1, NP_008944.1

OpenTargets

ENSG00000123124

IntEnz

2.3.2.26

HPA

ENSG00000123124-WWP1

GeneCards

Q9H0M0

Ensembl

ENST00000517970, ENSG00000123124, ENST00000265428, ENSP00000265428, ENSP00000427793

PRO

Q9H0M0

Pharos - Targets

Q9H0M0

HMDB Protein

HMDBP09262

PDB

1ND7, 8EI4, 6J1Y, 5HPS, 2OP7, 5HPT, 6J1X

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.805	9
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.783	6
UniProt:Q96B67 ARRD3			0.742	5
UniProt:Q8N5I2 ARRD1			0.742	5
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q96D16 Q96D16			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q8WU02 Q8WU02			0.556	3
UniProt:Q15884 EREP1			0.547	3
UniProt:Q8N0X7 SPART			0.527	2
UniProt:Q96J02 ITCH	2	Ub-C871-ITCH [cytosol] (R-HSA-8864515) ITCH [cytosol] (R-HSA-975995)	0.527	2
UniProt:Q8TBH0 ARRD2			0.527	2
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.527	2
UniProt:Q8NCT1 ARRD4			0.527	2

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