Reactome | LARP1 [cytosol]

LARP1 [cytosol]

Stable Identifier

R-HSA-9760421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

La-related protein 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        LARP1 binds SARS-CoV-2 RNA (Homo sapiens)
        
        LARP1 [cytosol] (Homo sapiens)
        
        LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
        
        LARP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6PKG0 LARP1

Gene Names

LARP1, KIAA0731, LARP

Chain

initiator methionine:1, chain:2-1096

Reference Genes

BioGPS Gene:23367 LARP1

COSMIC (genes):LARP1 LARP1

CTD Gene:23367 LARP1

dbSNP Gene:23367 LARP1

ENSEMBL:ENSG00000155506 LARP1

ENSEMBL:ENSG00000155506.19 LARP1

HGNC:29531 LARP1

KEGG Gene (Homo sapiens):23367 LARP1

Monarch:23367 LARP1

NCBI Gene:23367 LARP1

OMIM:612059 LARP1

UCSC:Q6PKG0 LARP1

Reference Transcript

Other Identifiers

11716476_a_at

11716477_x_at

11716478_s_at

16991385

210966_PM_x_at

210966_x_at

212137_PM_at

212137_at

212193_PM_s_at

212193_s_at

23367

239663_3p_x_at

239663_PM_x_at

239663_x_at

2836755

2836756

2836757

2836766

2836767

2836768

2836769

2836770

2836771

2836772

2836793

2836794

2836796

2836797

2836798

2836799

2836800

2836801

2836803

2836805

2836808

2836809

2836810

2836811

2836812

2836818

2836819

2836820

2836821

2836824

2836825

2836826

2836827

2836849

2899187

41829_at

8109438

89317_i_at

89319_r_at

A_14_P105840

A_14_P117612

A_23_P156319

A_23_P392383

GE53447

GE83654

GO:0000339

GO:0000340

GO:0003723

GO:0003730

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0005844

GO:0006412

GO:0006413

GO:0006417

GO:0006914

GO:0008190

GO:0008283

GO:0008494

GO:0010494

GO:0010608

GO:0016020

GO:0016071

GO:0016239

GO:0017148

GO:0023052

GO:0031369

GO:0031929

GO:0031931

GO:0038202

GO:0042788

GO:0043024

GO:0043226

GO:0045070

GO:0045182

GO:0045296

GO:0045727

GO:0045947

GO:0045948

GO:0048027

GO:0048255

GO:0072752

GO:1990928

HMNXSV003003041

Hs.207988.0.A1_3p_at

Hs.207988.0.A1_3p_s_at

Hs.207988.0.A1_3p_x_at

Hs.6214.1.A1_3p_a_at

Hs.75874.1.S1_3p_at

ILMN_1681590

ILMN_1812395

PH_hs_0000630

TC05000855.hg

TC05002704.hg

Participates

as a component of

LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)

as an input of

LARP1 binds SARS-CoV-2 RNA (Homo sapiens)

Cross References

RefSeq

NP_056130.2, XP_005268461.1

OpenTargets

ENSG00000155506

HPA

ENSG00000155506-LARP1

GeneCards

Q6PKG0

Ensembl

ENSG00000155506, ENSP00000336721, ENST00000336314, ENSP00000428589, ENST00000518297

PRO

Q6PKG0

Pharos - Targets

Q6PKG0

PDB

4ZC4, 6PW3, 5C0V, 5V4R, 5V87, 5V7C

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.788	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.702	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	4
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.597	5
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.589	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.589	2
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:Q12905 ILF2	5	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [cytosol] (R-HSA-9836392)	0.527	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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