Reactome | FBXO2 [cytosol]

FBXO2 [cytosol]

Stable Identifier

R-HSA-976044

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box only protein 2, FBX2_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UK22 FBXO2

Gene Names

FBXO2, FBX2

Chain

chain:1-296

Reference Genes

BioGPS Gene:26232 FBXO2

COSMIC (genes):FBXO2 FBXO2

CTD Gene:26232 FBXO2

dbSNP Gene:26232 FBXO2

ENSEMBL:ENSG00000116661 FBXO2

HGNC:13581 FBXO2

KEGG:hsa:26232 FBXO2

Monarch:26232 FBXO2

NCBI Gene:26232 FBXO2

OMIM:607112 FBXO2

UCSC:Q9UK22 FBXO2

Reference Transcript

RefSeq:NM_012168.5 FBXO2

Other Identifiers

11722234_x_at

11722235_a_at

11722236_at

16681735

219305_PM_x_at

219305_x_at

2396756

2396759

2396760

2396761

2396762

2396763

2396764

2396765

2396766

2396767

2396770

2396771

2396773

2396776

26232

57811_at

7912473

86983_at

A_23_P45999

GE481447

GE81762

GE88178

GO:0001540

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0006508

GO:0006511

GO:0006516

GO:0008285

GO:0016020

GO:0016567

GO:0016740

GO:0019005

GO:0030163

GO:0030246

GO:0031146

GO:0031249

GO:0031396

GO:0036211

GO:0036503

GO:0043197

GO:0043226

GO:0061630

GO:0098890

GO:0098978

GO:0099576

GO:0140096

GO:1901135

HMNXSV003052169

ILMN_1803211

PH_hs_0007951

PH_hs_0031749

TC01002199.hg

TC01005265.hg

g6912363_3p_at

p26578

Participates

as a member of

F-box protein [cytosol] (Homo sapiens)

Inferred To

fbxo2 [cytosol] (Danio rerio)

fbxo2 [cytosol] (Xenopus tropicalis)

Fbxo2 [cytosol] (Mus musculus)

Fbxo2 [cytosol] (Rattus norvegicus)

FBXO2 [cytosol] (Bos taurus)

FBXO2 [cytosol] (Caenorhabditis elegans)

FBXO2 [cytosol] (Canis familiaris)

FBXO2 [cytosol] (Gallus gallus)

FBXO2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_036300.2

OpenTargets

ENSG00000116661

ENSEMBL

ENST00000354287, ENSP00000346240, ENSG00000116661

GeneCards

FBXO2

HPA

ENSG00000116661-FBXO2

PRO

Q9UK22

Pharos - Targets

Q9UK22

GlyGen

Q9UK22

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.887	15
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.643	3
UniProt:Q86YB8 ERO1B	1	ERO1B [endoplasmic reticulum lumen] (R-HSA-4084704)	0.643	4
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	3
UniProt:Q8NAT1 POMGNT2	1	POMGNT2 [endoplasmic reticulum membrane] (R-HSA-8879119)	0.527	3
UniProt:Q58EX2 SDK2	1	SDK2 [plasma membrane] (R-HSA-3006484)	0.527	2
UniProt:Q99538 LGMN	2	LGMN [endolysosome lumen] (R-HSA-8942384) LGMN [lysosomal lumen] (R-HSA-350135)	0.527	3
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.527	3
UniProt:Q8NCC3 PLA2G15	1	PLA2G15 [extracellular region] (R-HSA-8933312)	0.527	3
UniProt:P14543 NID1	3	NID1(?-1247) [extracellular region] (R-HSA-2533960) NID1(29-?) [extracellular region] (R-HSA-2533959) NID1 [extracellular region] (R-HSA-383375)	0.527	2
UniProt:P35555 FBN1	7	FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1 [extracellular region] (R-HSA-265402) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.527	2
UniProt:Q14118 DAG1	20	DAG1(654-895) [plasma membrane] (R-HSA-2328154) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) Core M1,3-DAG1 [Golgi lumen] (R-HSA-5617087) Core M1,2,3-DAG1 [Golgi lumen] (R-HSA-8932424) Core M3-DAG1 [Golgi lumen] (R-HSA-9940750) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940668) Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940723) RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940763) GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940727) Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940697) Matriglycan-DAG1 [Golgi lumen] (R-HSA-9940706) 3S-Matriglycan-DAG1 [Golgi lumen] (R-HSA-9940731)	0.527	2
UniProt:Q96F46 IL17RA	1	IL17RA [plasma membrane] (R-HSA-447176)	0.527	3
UniProt:P78536 ADAM17	6	ADAM17 [plasma membrane] (R-HSA-179878) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763)	0.527	3
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.527	3
UniProt:Q13332 PTPRS	1	PTPRS [plasma membrane] (R-HSA-197680)	0.527	3
UniProt:Q96FT7 ASIC4	1	ASIC4 [plasma membrane] (R-HSA-2671913)	0.527	3
UniProt:Q96JA1 LRIG1	2	LRIG1 [plasma membrane] (R-HSA-197745) Ub-LRIG1 [plasma membrane] (R-HSA-8875434)	0.527	2
UniProt:P18850 ATF6	7	ATF6 [endoplasmic reticulum membrane] (R-HSA-381222) ATF6 [Golgi membrane] (R-HSA-381000) ATF6(1-419) [Golgi membrane] (R-HSA-420815) ATF6(1-380) [cytosol] (R-HSA-381075) ATF6(380-419) [Golgi membrane] (R-HSA-420817) ATF6(420-670) [Golgi membrane] (R-HSA-420814) ATF6(1-380) [nucleoplasm] (R-HSA-381211)	0.527	3
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.527	3
UniProt:O00468 AGRN	20	HS(4)-AGRN [plasma membrane] (R-HSA-2076654) HS(6)-AGRN [plasma membrane] (R-HSA-2076678) HS(2)-AGRN [plasma membrane] (R-HSA-2076686) HS(1)-AGRN [plasma membrane] (R-HSA-2076634) HS(3)-AGRN [plasma membrane] (R-HSA-2076663) HS(5)-AGRN [plasma membrane] (R-HSA-2076642) AGRN(30-2045) [extracellular region] (R-HSA-375056) AGRN(30-2045) [Golgi lumen] (R-HSA-2054104) XylS-AGRN(30-2045) [Golgi lumen] (R-HSA-2064220) Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064130) Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064040) GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen] (R-HSA-2064200) Heparan-AGRN [Golgi lumen] (R-HSA-2076530) Heparan(1)-AGRN [Golgi lumen] (R-HSA-2076317) Heparan(2)-AGRN [Golgi lumen] (R-HSA-2076301) Heparan(3)-AGRN [Golgi lumen] (R-HSA-2076569) Heparan(4)-AGRN [Golgi lumen] (R-HSA-2076300) HS(1)-AGRN [Golgi lumen] (R-HSA-2076350) HS(2)-AGRN [Golgi lumen] (R-HSA-2076521) HS(3)-AGRN [Golgi lumen] (R-HSA-2076493)	0.527	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.527	3
UniProt:Q8N2S1 LTBP4	1	LTBP4 [extracellular region] (R-HSA-2161309)	0.527	2
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.527	3
UniProt:Q8NCR0 B3GALNT2	1	B3GALNT2 [endoplasmic reticulum membrane] (R-HSA-8878916)	0.527	3
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.527	2
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	3
UniProt:Q8NBL1 POGLUT1	1	POGLUT1 [endoplasmic reticulum lumen] (R-HSA-1464796)	0.527	3
UniProt:Q99650 OSMR	1	OSMR [plasma membrane] (R-HSA-448654)	0.527	2
UniProt:Q08722 CD47	3	CD47 [plasma membrane] (R-HSA-197736) CD47 [specific granule membrane] (R-HSA-6799523) CD47 [tertiary granule membrane] (R-HSA-6801033)	0.527	2
UniProt:P40189 IL6ST	2	IL6ST [plasma membrane] (R-HSA-448453) p-Y-IL6ST [plasma membrane] (R-HSA-8950439)	0.527	2
UniProt:P05154 SERPINA5	1	SERPINA5 [extracellular region] (R-HSA-5591085)	0.527	2
UniProt:Q8WXG9 ADGRV1	1	GPR98 [plasma membrane] (R-HSA-9618718)	0.527	2
UniProt:P32004 L1CAM	7	L1CAM [plasma membrane] (R-HSA-191465) p-Y1229-L1CAM [plasma membrane] (R-HSA-444980) p-Y1176-L1CAM [plasma membrane] (R-HSA-444985) p-Y-L1CAM [plasma membrane] (R-HSA-443808) p-S1152-L1CAM [plasma membrane] (R-HSA-374599) p-S1204,S1248-L1CAM [plasma membrane] (R-HSA-444982) p-S1181-L1CAM [plasma membrane] (R-HSA-392737)	0.527	3
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.527	2
UniProt:Q9H488 POFUT1	1	POFUT1 [endoplasmic reticulum membrane] (R-HSA-1460374)	0.527	3
UniProt:P54802 NAGLU	5	NAGLU R674C [lysosomal lumen] (R-HSA-2219558) NAGLU R674H [lysosomal lumen] (R-HSA-2219557) NAGLU R626* [lysosomal lumen] (R-HSA-2219568) NAGLU R297* [lysosomal lumen] (R-HSA-2219553) NAGLU(59-743) [lysosomal lumen] (R-HSA-1678772)	0.527	3
UniProt:P42702 LIFR	1	LIFR [plasma membrane] (R-HSA-5693181)	0.527	3
UniProt:P98160 HSPG2	20	HSPG2(22-4196) [extracellular region] (R-HSA-3827968) HSPG2(4197-4391) [extracellular region] (R-HSA-3827980) HS(4)-HSPG2 [plasma membrane] (R-HSA-2076698) HS(6)-HSPG2 [plasma membrane] (R-HSA-2076681) HS(2)-HSPG2 [plasma membrane] (R-HSA-2076659) HS(1)-HSPG2 [plasma membrane] (R-HSA-2076680) HS(3)-HSPG2 [plasma membrane] (R-HSA-2076627) HS(5)-HSPG2 [plasma membrane] (R-HSA-2076679) HSPG2(3687-4391) [extracellular region] (R-HSA-4088241) HSPG2(22-4391) [Golgi lumen] (R-HSA-2054109) XylS-HSPG2(22-4391) [Golgi lumen] (R-HSA-2063972) Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064209) Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2063971) GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064023) Heparan-HSPG2 [Golgi lumen] (R-HSA-2076367) Heparan(1)-HSPG2 [Golgi lumen] (R-HSA-2076585) Heparan(2)-HSPG2 [Golgi lumen] (R-HSA-2076335) Heparan(3)-HSPG2 [Golgi lumen] (R-HSA-2076334) Heparan(4)-HSPG2 [Golgi lumen] (R-HSA-2076395) HS(1)-HSPG2 [Golgi lumen] (R-HSA-2076366)	0.527	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	3
UniProt:Q9Y251 HPSE	9	proHPSE [extracellular region] (R-HSA-9792564) proHPSE [plasma membrane] (R-HSA-9792566) proHPSE [lysosomal lumen] (R-HSA-9792563) HPSE(158-543) [lysosomal lumen] (R-HSA-1666989) HPSE(36-109) [lysosomal lumen] (R-HSA-1667006) HPSE(158-543) [specific granule lumen] (R-HSA-6806147) HPSE(36-109) [specific granule lumen] (R-HSA-6806153) HPSE(158-543) [extracellular region] (R-HSA-6806159) HPSE(36-109) [extracellular region] (R-HSA-6806162)	0.527	3
UniProt:O15118 NPC1	1	NPC1 [lysosomal membrane] (R-HSA-5216153)	0.527	3
UniProt:P43251 BTD	13	BTD [extracellular region] (R-HSA-3076888) BTD [mitochondrial matrix] (R-HSA-4167525) BTD C33Ffs36 [extracellular region] (R-HSA-3325555) BTD Q456H [extracellular region] (R-HSA-3325552) BTD R538C [extracellular region] (R-HSA-3325543) BTD A171T [extracellular region] (R-HSA-3325576) BTD R79C [extracellular region] (R-HSA-3325545) BTD R538C [mitochondrial matrix] (R-HSA-4225078) BTD G34S [mitochondrial matrix] (R-HSA-4225079) BTD A171T [mitochondrial matrix] (R-HSA-4225080) BTD C33Ffs36 [mitochondrial matrix] (R-HSA-4225081) BTD Q456H [mitochondrial matrix] (R-HSA-4225082) BTD R79C [mitochondrial matrix] (R-HSA-4225085)	0.527	2
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.527	2
UniProt:O75462 CRLF1	2	CRLF1 [cytosol] (R-HSA-8950296) CRLF1 [extracellular region] (R-HSA-5693174)	0.527	3
UniProt:Q9BTN0 LRFN3	1	SALM4 [plasma membrane] (R-HSA-197704)	0.527	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.527	3
UniProt:P08648 ITGA5	3	ITGA5(42-894) [plasma membrane] (R-HSA-202735) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5 [plasma membrane] (R-HSA-9857636)	0.527	3
UniProt:Q99941 ATF6B	7	ATF6B [endoplasmic reticulum membrane] (R-HSA-8874179) ATF6B [Golgi membrane] (R-HSA-8874154) ATF6B(2-440) [Golgi membrane] (R-HSA-8874148) ATF6B(441-703) [Golgi membrane] (R-HSA-8874147) ATF6B(2-398) [cytosol] (R-HSA-8874143) ATF6B(399-440) [Golgi membrane] (R-HSA-8874171) ATF6B(2-398) [nucleoplasm] (R-HSA-8874178)	0.527	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	3
UniProt:P00750 PLAT	3	PLAT(36-562) [extracellular region] (R-HSA-158754) PLAT(36-310) [extracellular region] (R-HSA-158758) PLAT(311-562) [extracellular region] (R-HSA-158762)	0.527	2

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