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TRIP12 [cytosol]
Stable Identifier
R-HSA-976046
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable E3 ubiquitin-protein ligase TRIP12, TRIPC_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIP12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14669 TRIP12
Gene Names
TRIP12, KIAA0045, ULF
Chain
initiator methionine:, chain:2-1992
Reference Genes
BioGPS Gene:9320 TRIP12
COSMIC (genes):TRIP12 TRIP12
CTD Gene:9320 TRIP12
dbSNP Gene:9320 TRIP12
ENSEMBL:ENSG00000153827 TRIP12
ENSEMBL_homo_sapiens_GENE:ENSG00000153827.15 TRIP12
HGNC:12306 TRIP12
Monarch:9320 TRIP12
NCBI Gene:9320 TRIP12
OMIM:604506 TRIP12
UCSC:Q14669 TRIP12
Reference Transcript
RefSeq:NM_001348316.1 TRIP12
RefSeq:NM_004238.2 TRIP12
RefSeq:NM_001284216.1 TRIP12
RefSeq:NM_001348315.1 TRIP12
RefSeq:NM_001284214.1 TRIP12
RefSeq:NM_001284215.2 TRIP12
Other Identifiers
11715810_a_at
11748813_a_at
16909339
201546_PM_at
201546_at
226993_PM_at
226993_at
2602895
2602897
2602898
2602900
2602902
2602903
2602904
2602905
2602906
2602908
2602909
2602910
2602916
2602917
2602918
2602919
2602921
2602923
2602924
2602925
2602927
2602931
2602932
2602933
2602934
2602935
2602938
2602939
2602940
2602941
2602942
2602944
2602945
2602946
2602947
2602948
2602949
2602950
2602952
2602953
2602954
2602955
2602956
2602957
2602958
2602959
2602961
2602963
2602965
2602971
2602973
2602975
2602976
2602977
2602978
2602981
2602982
2602988
39699_at
58206_at
8059596
9320
A_23_P147984
A_24_P325691
A_24_P938281
A_32_P188178
D28476_at
GE57147
GE862118
GE86250
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006281
GO:0006325
GO:0006511
GO:0006974
GO:0008270
GO:0016567
GO:0016607
GO:0016740
GO:0030163
GO:0033696
GO:0036211
GO:0043161
GO:0043226
GO:0045995
GO:0046966
GO:0048856
GO:0061630
GO:0140096
GO:0140861
HMNXSV003058195
Hs.322915.0.A1_3p_at
Hs.322915.0.A1_3p_x_at
ILMN_1720241
ILMN_1841620
PH_hs_0024464
TC02002848.hg
g10863902_3p_at
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
TRIP12 [cytosol]
(Bos taurus)
TRIP12 [cytosol]
(Canis familiaris)
TRIP12 [cytosol]
(Dictyostelium discoideum)
TRIP12 [cytosol]
(Gallus gallus)
TRIP12 [cytosol]
(Plasmodium falciparum)
TRIP12 [cytosol]
(Schizosaccharomyces pombe)
TRIP12 [cytosol]
(Sus scrofa)
UFD4 [cytosol]
(Saccharomyces cerevisiae)
ctrip [cytosol]
(Drosophila melanogaster)
Trip12 [cytosol]
(Mus musculus)
Trip12 [cytosol]
(Rattus norvegicus)
trip12 [cytosol]
(Danio rerio)
trip12 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001335245.1
,
NP_001271143.1
,
NP_004229.1
,
NP_001271144.1
,
NP_001271145.1
,
NP_001335244.1
OpenTargets
ENSG00000153827
HPA
ENSG00000153827-TRIP12
GeneCards
Q14669
Ensembl
ENST00000704580
,
ENST00000283943
,
ENSG00000153827
,
ENSP00000373697
,
ENSP00000373696
,
ENSP00000283943
,
ENST00000389044
,
ENSP00000515955
,
ENST00000389045
PRO
Q14669
Pharos - Targets
Q14669
Orphanet
25002
HMDB Protein
HMDBP09328
PDB
7UW7
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.632
7
UniProt:Q8N726 CDKN2A
12
p14ARF [nucleoplasm]
(R-HSA-1629813)
p14ARF [cytosol]
(R-HSA-9645669)
p14ARF [mitochondrial matrix]
(R-HSA-9645695)
p14ARF R98L;R99S [cytosol]
(R-HSA-9645730)
p14ARF R82C [cytosol]
(R-HSA-9645750)
p14ARF R90H [cytosol]
(R-HSA-9645755)
p14ARF R88Q [cytosol]
(R-HSA-9645754)
p14ARF R87C [cytosol]
(R-HSA-9645759)
p14ARF R81G [cytosol]
(R-HSA-9645741)
p14ARF R98Q [cytosol]
(R-HSA-9645757)
p14ARF R99C [cytosol]
(R-HSA-9645756)
p14ARF V22Pfs*46 [cytosol]
(R-HSA-9646285)
0.602
4
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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