Reactome | TRIM37 [cytosol]

TRIM37 [cytosol]

Stable Identifier

R-HSA-976049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase TRIM37, TRI37_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O94972 TRIM37

Gene Names

TRIM37, KIAA0898, MUL, POB1

Chain

chain:1-964

Reference Genes

BioGPS Gene:4591 TRIM37

COSMIC (genes):TRIM37 TRIM37

CTD Gene:4591 TRIM37

dbSNP Gene:4591 TRIM37

ENSEMBL:ENSG00000108395 TRIM37

ENSEMBL_homo_sapiens_GENE:ENSG00000108395.14 TRIM37

HGNC:7523 TRIM37

KEGG Gene (Homo sapiens):4591 TRIM37

Monarch:4591 TRIM37

NCBI Gene:4591 TRIM37

OMIM:605073 TRIM37

UCSC:O94972 TRIM37

Reference Transcript

Other Identifiers

11721084_a_at

11721085_a_at

11730164_a_at

11748457_a_at

1554001_PM_at

1554001_at

16847209

213009_PM_s_at

213009_s_at

33107_at

3764681

3764690

3764691

3764693

3764696

3764697

3764698

3764702

3764703

3764704

3764705

3764707

3764708

3764709

3764710

3764711

3764712

3764714

3764716

3764718

3764719

3764720

3764722

3764724

3764726

3764728

3764731

3764732

3764733

4591

8017106

A_23_P21230

A_24_P153853

GE53570

GO:0000122

GO:0003682

GO:0003713

GO:0003824

GO:0004842

GO:0005164

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005777

GO:0005778

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0006513

GO:0006886

GO:0007010

GO:0007031

GO:0008270

GO:0016020

GO:0016235

GO:0016558

GO:0016567

GO:0016740

GO:0019899

GO:0031625

GO:0032088

GO:0035098

GO:0036211

GO:0042802

GO:0042803

GO:0043226

GO:0045814

GO:0045893

GO:0046600

GO:0046872

GO:0048471

GO:0050821

GO:0051091

GO:0051092

GO:0051865

GO:0055085

GO:0061630

GO:0070842

GO:0140096

GO:0140110

GO:0140862

HMNXSV003046598

HMNXSV003050609

Hs.8164.0.S1_3p_a_at

Hs2.8164.2.S1_3p_at

ILMN_1671513

ILMN_1704383

ILMN_1711327

PH_hs_0040431

TC17001743.hg

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

TRIM37 [cytosol] (Bos taurus)

TRIM37 [cytosol] (Canis familiaris)

TRIM37 [cytosol] (Dictyostelium discoideum)

TRIM37 [cytosol] (Gallus gallus)

TRIM37 [cytosol] (Mus musculus)

TRIM37 [cytosol] (Sus scrofa)

Trim37 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001307916.1, NP_001005207.1, NP_001307919.1, NP_056109.1

OpenTargets

ENSG00000108395

HPA

ENSG00000108395-TRIM37

GeneCards

O94972

Ensembl

ENSP00000376785, ENSP00000376784, ENSG00000108395, ENST00000262294, ENST00000393066, ENST00000393065, ENSP00000262294

PRO

O94972

Pharos - Targets

O94972

Orphanet

15663

PDB

3LRQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.781	9
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.739	6
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.718	6
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.666	4
UniProt:O43663 PRC1	1	PRC1 [cytosol] (R-HSA-264441)	0.635	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O00311 CDC7	1	CDC7 [nucleoplasm] (R-HSA-51781)	0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.556	3
UniProt:Q7L590 MCM10	1	MCM10 [nucleoplasm] (R-HSA-68403)	0.553	2