Reactome | UHRF2 [nucleoplasm]

UHRF2 [nucleoplasm]

Stable Identifier

R-HSA-976050

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase UHRF2, UHRF2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription cofactors (Homo sapiens)
        
        CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
        
        CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
        
        UHRF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PU4 UHRF2

Gene Names

UHRF2, NIRF, RNF107

Chain

chain:1-802

Reference Genes

BioGPS Gene:115426 UHRF2

COSMIC (genes):UHRF2 UHRF2

CTD Gene:115426 UHRF2

dbSNP Gene:115426 UHRF2

ENSEMBL:ENSG00000147854 UHRF2

HGNC:12557 UHRF2

Monarch:115426 UHRF2

NCBI Gene:115426 UHRF2

OMIM:615211 UHRF2

UCSC:Q96PU4 UHRF2

Reference Transcript

RefSeq:NM_152896.2 UHRF2

Other Identifiers

115426

11718186_a_at

17083452

225610_PM_at

225610_at

3161399

3161400

3161401

3161402

3161404

3161406

3161408

3161409

3161410

3161411

3161419

3161423

3161424

3161425

3161426

3161427

3161428

3161429

3161431

3161432

3161433

3161434

3161435

3161436

3161437

3161439

3161440

3161441

3161442

3161444

3161445

3161447

3161448

3981838

3981861

53732_at

8154316

82695_at

A_23_P9144

A_24_P303815

A_33_P3279715

GE482538

GE56796

GO:0000792

GO:0003677

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0006325

GO:0016567

GO:0016740

GO:0016925

GO:0019789

GO:0030154

GO:0042393

GO:0043226

GO:0044027

GO:0046872

GO:0051726

GO:0051865

GO:0061629

GO:0061630

GO:0140096

HMNXSV003033558

HMNXSV003050641

Hs.12258.0.S1_3p_at

ILMN_1691444

PH_hs_0024552

PH_hs_0033103

TC09000047.hg

Participates

as a member of

CBX4, UHRF2 [nucleoplasm] (Homo sapiens)

Inferred To

Uhrf2 [nucleoplasm] (Mus musculus)

Uhrf2 [nucleoplasm] (Rattus norvegicus)

UHRF2 [nucleoplasm] (Bos taurus)

UHRF2 [nucleoplasm] (Gallus gallus)

uhrf2 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000276893, ENST00000468435, ENSP00000434182, ENST00000276893

OpenTargets

ENSG00000147854

HPA

ENSG00000147854-UHRF2

PRO

Q96PU4

Pharos - Targets

Q96PU4

GlyGen

Q96PU4

PDB

4PW6, 4TVR, 4PW7, 1Z6U, 3OLN, 5YCO, 1WY8, 2E6S, 4PW5

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.729	5
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.602	4
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.602	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.591	4
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.553	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3

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