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PAX2 [nucleoplasm]
Stable Identifier
R-HSA-9761175
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Paired box protein Pax-2, PAX2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of intermediate mesoderm (Homo sapiens)
Expression of LHX1 in intermediate mesoderm (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of OSR1 in intermediate mesoderm (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of PAX2 in intermediate mesoderm (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 binds the LHX1 gene (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of EMX2 in the nephric duct (Homo sapiens)
PAX2:EMX2 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of ID4 in the nephric duct (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of LHX1 (LIM1) in the nephric duct (Homo sapiens)
GATA3:PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of PAX2 in intermediate mesoderm (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of PAX2 in the nephric duct (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of PLAC8 in the nephric duct (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:PLAC8 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of WFDC2 in the nephric duct (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
GATA3 binds the LHX1 gene (Homo sapiens)
GATA3:PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 binds the EMX2 gene (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:EMX2 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 binds the LHX1 gene (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 binds the PLAC8 gene (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2:PLAC8 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Formation of the ureteric bud (Homo sapiens)
EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)
EYA1:PAX2:HOX11 paralog:GDNF gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
EYA1, PAX2, and HOX11 paralog bind the SIX2 gene (Homo sapiens)
EYA1:PAX2:HOX11 paralog:SIX2 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of GDNF in metanephric mesenchyme (Homo sapiens)
EYA1:PAX2:HOX11 paralog:GDNF gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of PAX2 in metanephric mesenchyme (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
Expression of SIX2 in metanephric mesenchyme (Homo sapiens)
EYA1:PAX2:HOX11 paralog:SIX2 gene [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
PAX2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02962 PAX2
Gene Names
PAX2
Chain
chain:1-417
Reference Genes
BioGPS Gene:5076 PAX2
COSMIC (genes):PAX2 PAX2
CTD Gene:5076 PAX2
dbSNP Gene:5076 PAX2
ENSEMBL:ENSG00000075891 PAX2
HGNC:8616 PAX2
KEGG:hsa:5076 PAX2
Monarch:5076 PAX2
NCBI Gene:5076 PAX2
OMIM:167409 PAX2
UCSC:Q02962 PAX2
Reference Transcript
RefSeq:NM_003989.4 PAX2
RefSeq:NM_003988.4 PAX2
RefSeq:NM_003987.4 PAX2
RefSeq:NM_003990.4 PAX2
RefSeq:NM_001304569.1 PAX2
RefSeq:NM_000278.4 PAX2
Other Identifiers
11728623_a_at
11728624_a_at
16708293
206228_PM_at
206228_at
206229_PM_x_at
206229_x_at
3260740
3260749
3260750
3260751
3260752
3260753
3260754
3260755
3260756
3260757
3260766
3260767
3260771
3260779
3260780
3260782
3260783
3260784
3260785
3260794
3260795
3260797
3260798
3260799
3260800
3260801
3260802
3260803
3260804
3260805
3260806
38184_at
38185_at
38186_g_at
5076
7929840
A_14_P124273
A_33_P3343066
A_33_P3380850
GE58319
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001655
GO:0001658
GO:0001709
GO:0001823
GO:0001843
GO:0002072
GO:0003337
GO:0003406
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005815
GO:0006355
GO:0006357
GO:0007409
GO:0007501
GO:0007601
GO:0008134
GO:0008284
GO:0010001
GO:0021554
GO:0021631
GO:0021633
GO:0021650
GO:0030154
GO:0031667
GO:0032991
GO:0032993
GO:0034451
GO:0035566
GO:0035799
GO:0039003
GO:0042472
GO:0043010
GO:0043066
GO:0043069
GO:0043154
GO:0043226
GO:0045892
GO:0045893
GO:0045944
GO:0048793
GO:0048854
GO:0048856
GO:0048863
GO:0050679
GO:0050877
GO:0060231
GO:0061360
GO:0071300
GO:0071333
GO:0071364
GO:0072075
GO:0072108
GO:0072162
GO:0072179
GO:0072189
GO:0072205
GO:0072207
GO:0072221
GO:0072289
GO:0072300
GO:0072305
GO:0072307
GO:0090102
GO:0090103
GO:0140110
GO:1900212
GO:1900215
GO:1900218
GO:1990837
GO:2000378
GO:2000594
GO:2000597
HMNXSV003004795
Hs.155644.0.S2_3p_at
ILMN_1734365
ILMN_1739400
ILMN_2353490
M89470_s_at
PH_hs_0029252
TC10000725.hg
U45255_s_at
g4557824_3p_a_at
p33903
Participates
as an input of
PAX2 binds the PLAC8 gene (Homo sapiens)
PAX2 binds the EMX2 gene (Homo sapiens)
PAX2 binds the LHX1 gene (Homo sapiens)
EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)
EYA1, PAX2, and HOX11 paralog bind the SIX2 gene (Homo sapiens)
as a component of
PAX2:PLAC8 gene [nucleoplasm] (Homo sapiens)
PAX2:EMX2 gene [nucleoplasm] (Homo sapiens)
GATA3:PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
PAX2:LHX1 gene [nucleoplasm] (Homo sapiens)
EYA1:PAX2:HOX11 paralog:GDNF gene [nucleoplasm] (Homo sapiens)
EYA1:PAX2:HOX11 paralog:SIX2 gene [nucleoplasm] (Homo sapiens)
as an output of
Expression of PAX2 in the nephric duct (Homo sapiens)
Expression of PAX2 in intermediate mesoderm (Homo sapiens)
Expression of PAX2 in metanephric mesenchyme (Homo sapiens)
This entity regulates
Positively
Expression of MECOM (EVI1) in the nephric duct
(Homo sapiens)
Expression of ID4 in the nephric duct
(Homo sapiens)
Expression of WFDC2 in the nephric duct
(Homo sapiens)
Expression of OSR1 in intermediate mesoderm
(Homo sapiens)
Cross References
ENSEMBL
ENST00000370296
,
ENSP00000347385
,
ENST00000355243
,
ENSP00000396259
,
ENSG00000075891
,
ENST00000428433
,
ENSP00000359319
OpenTargets
ENSG00000075891
GeneCards
PAX2
HPA
ENSG00000075891-PAX2
PRO
Q02962
Pharos - Targets
Q02962
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60663-2 LMX1B
0.508
3
UniProt:O00712 NFIB
1
NFIB [nucleoplasm]
(R-HSA-60136)
0.471
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
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