Reactome | AMOT-2 [cytosol]

AMOT-2 [cytosol]

Stable Identifier

R-HSA-9761473

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMOT-p80, Angiomotin-p80

Locations in the PathwayBrowser for interactor UniProt:P61968 LMO4

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 function (Homo sapiens)
        
        AMOT-2 binds CDH11 (Homo sapiens)
        
        AMOT-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q4VCS5-2 AMOT

Gene Names

AMOT, KIAA1071

Participates

as a component of

CDH11:CTNND1:CTNNB1:AMOT-2 [plasma membrane] (Homo sapiens)

as an input of

AMOT-2 binds CDH11 (Homo sapiens)

Inferred To

Amot [cytosol] (Mus musculus)

Amot [cytosol] (Rattus norvegicus)

AMOT [cytosol] (Bos taurus)

AMOT [cytosol] (Canis familiaris)

AMOT [cytosol] (Gallus gallus)

AMOT [cytosol] (Sus scrofa)

amot [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000126016

ENSEMBL

ENST00000371959, ENSP00000305557, ENSG00000126016, ENSP00000361027, ENST00000304758

HPA

ENSG00000126016-AMOT

GeneCards

AMOT

PRO

Q4VCS5

Pharos - Targets

Q4VCS5

GlyGen

Q4VCS5

PDB

7NPG, 7NN2, 7NND, 7NNE, 7NPB, 7OQW, 7OQU, 7NMW, 7LP2, 7NMA, 7NMX, 7NP2, 7OQJ, 7OQG, 7OQS, 7LP5, 7LP3, 6JJX

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.882	10
UniProt:Q8N3R9 MPP5	2	MPP5 [plasma membrane] (R-HSA-419969) MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606)	0.802	7
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.802	6
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.615	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.527	2
UniProt:Q96PU5 NEDD4L	2	NEDD4L [nucleoplasm] (R-HSA-2176420) NEDD4L [cytosol] (R-HSA-976003)	0.527	2
UniProt:P46662	1	Nf2 [plasma membrane] (R-MMU-5669168)	0.499	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.499	3

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