Reactome | TPH1 [cytosol]

TPH1 [cytosol]

Stable Identifier

R-HSA-976250

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tryptophan 5-hydroxylase 1, TPH1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of amino acids and derivatives (Homo sapiens)
  - Metabolism of amine-derived hormones (Homo sapiens)
    - Serotonin and melatonin biosynthesis (Homo sapiens)
      - Tryptophan is hydroxylated (Homo sapiens)
        
        TPH:Fe++ [cytosol] (Homo sapiens)
        
        TPH [cytosol] (Homo sapiens)
        
        TPH1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        TPH1 gene expression (Homo sapiens)
        
        TPH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17752 TPH1

Gene Names

TPH1, TPH, TPRH, TRPH

Chain

chain:1-444

Reference Genes

BioGPS Gene:7166 TPH1

COSMIC (genes):TPH1 TPH1

CTD Gene:7166 TPH1

dbSNP Gene:7166 TPH1

ENSEMBL:ENSG00000129167 TPH1

HGNC:12008 TPH1

KEGG:hsa:7166 TPH1

Monarch:7166 TPH1

NCBI Gene:7166 TPH1

OMIM:191060 TPH1

UCSC:P17752 TPH1

Reference Transcript

RefSeq:NM_004179.2 TPH1

Other Identifiers

11740862_a_at

11740863_at

11757229_a_at

16736405

214601_PM_at

214601_at

231626_PM_at

231626_at

3365198

3365200

3365202

3365204

3365205

3365206

3365207

3365208

3365209

3365210

3365211

3365212

3365213

3365214

3365215

3365216

3365217

3365218

37879_r_at

7166

74393_at

7946946

A_23_P150595

GE54540

GE890019

GE902895

GO:0002576

GO:0003824

GO:0004497

GO:0004510

GO:0005506

GO:0005515

GO:0005737

GO:0005829

GO:0006520

GO:0007623

GO:0009072

GO:0016192

GO:0016491

GO:0016714

GO:0030279

GO:0035902

GO:0042427

GO:0043005

GO:0045600

GO:0046849

GO:0046872

GO:0048856

GO:0060749

GO:1900046

HMNXSV003056844

Hs.129056.0.A1_3p_at

Hs.144563.0.A2_3p_at

ILMN_1679115

ILMN_1817252

L29306_s_at

PH_hs_0024002

TC11003436.hg

Participates

as an output of

TPH1 gene expression (Homo sapiens)

as a member of

TPH [cytosol] (Homo sapiens)

Inferred To

TPH1 [cytosol] (Bos taurus)

TPH1 [cytosol] (Caenorhabditis elegans)

TPH1 [cytosol] (Canis familiaris)

TPH1 [cytosol] (Danio rerio)

TPH1 [cytosol] (Dictyostelium discoideum)

TPH1 [cytosol] (Drosophila melanogaster)

TPH1 [cytosol] (Gallus gallus)

TPH1 [cytosol] (Mus musculus)

TPH1 [cytosol] (Rattus norvegicus)

TPH1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004170.1

Guide to Pharmacology - Targets

1241

OpenTargets

ENSG00000129167

ENSEMBL

ENST00000682019, ENSP00000508368, ENST00000250018, ENSP00000250018

ZINC - Substances

TPH1_HUMAN

ZINC target

P17752

PRO

P17752

GlyGen

P17752

PDB

3HFB, 8CJO, 8CJJ, 7ZIK, 8CJN, 5L01, 3HF6, 8CJL, 8CJM, 8CJK, 7ZIJ, 1MLW, 7ZIG, 8CJI, 7ZII, 5J6D, 7ZIF, 7ZIH, 3HF8, 5TPG

HPA

ENSG00000129167-TPH1

Pharos - Targets

P17752

ZINC - Predictions - Purchasable

TPH1_HUMAN

HMDB Protein

HMDBP00469

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKB3 DJC12			0.623	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	5
UniProt:O95789-4 ZMYM6			0.556	3
UniProt:Q96IK1-2 Q96IK12			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	2
UniProt:Q6PCD5 RFWD3			0.527	2