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Go!
ub K420 p-S349 SQSTM1 [cytosol]
Stable Identifier
R-HSA-9766536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p62, Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
RBX1:CUL3 dissociates from forming autophagosome (Homo sapiens)
MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Homo sapiens)
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
ub K420 p-S349 SQSTM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13501 SQSTM1
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:, chain:2-440, initiator methionine:
Reference Genes
BioGPS Gene:8878 SQSTM1
COSMIC (genes):SQSTM1 SQSTM1
CTD Gene:8878 SQSTM1
dbSNP Gene:8878 SQSTM1
ENSEMBL:ENSG00000161011 SQSTM1
ENSEMBL_homo_sapiens_GENE:ENSG00000161011.20 SQSTM1
ENSEMBL_homo_sapiens_GENE:ENSG00000284099.3 SQSTM1
HGNC:11280 SQSTM1
KEGG Gene (Homo sapiens):8878 SQSTM1
Monarch:8878 SQSTM1
NCBI Gene:8878 SQSTM1
OMIM:601530 SQSTM1
UCSC:Q13501 SQSTM1
Reference Transcript
RefSeq:NM_001142298.1 SQSTM1
RefSeq:XM_017010010.1 SQSTM1
RefSeq:NM_001142299.1 SQSTM1
RefSeq:NM_003900.4 SQSTM1
Other Identifiers
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
201471_PM_s_at
201471_s_at
213112_PM_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
40898_at
8110569
8878
A_14_P109999
A_23_P81399
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0001934
GO:0002376
GO:0002931
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006511
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007005
GO:0007032
GO:0008104
GO:0008270
GO:0010508
GO:0010821
GO:0012501
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030017
GO:0030154
GO:0030163
GO:0030674
GO:0030971
GO:0031397
GO:0031410
GO:0031625
GO:0034144
GO:0035255
GO:0035556
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043065
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0044877
GO:0045944
GO:0046578
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0070062
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0097413
GO:0098542
GO:0098780
GO:0140036
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
HMNXSV003033729
Hs.279891.1.A1_3p_at
ILMN_1662618
PH_hs_0010763
U46751_at
g4505570_3p_s_at
Participates
as a component of
ub-K420 p-S349 SQSTM1 oligomer [cytosol] (Homo sapiens)
Other forms of this molecule
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
K7 ub-SQSTM1 [cytosol]
p-S349 SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
SQSTM1 [cytosol]
Inferred To
phospho-SQSTM1 [cytosol]
(Bos taurus)
phospho-SQSTM1 [cytosol]
(Canis familiaris)
phospho-SQSTM1 [cytosol]
(Gallus gallus)
phospho-SQSTM1 [cytosol]
(Sus scrofa)
phospho-ub K420 p-S349 SQSTM1 [cytosol]
(Dictyostelium discoideum)
phospho-ub K420 p-S349 SQSTM1 [cytosol]
(Drosophila melanogaster)
phospho-ub K420 p-S349 SQSTM1 [cytosol]
(Mus musculus)
phospho-ub K420 p-S349 SQSTM1 [cytosol]
(Rattus norvegicus)
phospho-gldi-4 [cytosol]
(Caenorhabditis elegans)
phospho-sqstm1 [cytosol]
(Danio rerio)
phospho-sqstm1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 349
Coordinate
349
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at 420
Coordinate
420
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_003891.1
,
NP_001135771.1
,
NP_001135770.1
,
XP_016865499.1
Guide to Pharmacology - Targets
3213
OpenTargets
ENSG00000161011
HPA
ENSG00000161011-SQSTM1
GeneCards
Q13501
Ensembl
ENSP00000495843
,
ENST00000360718
,
ENST00000640444
,
ENSP00000353944
,
ENSG00000161011
,
ENST00000389805
,
ENSP00000374455
,
ENSP00000491834
,
ENSG00000284099
,
ENST00000643389
PRO
Q13501
Pharos - Targets
Q13501
Orphanet
20429
PDB
5YP7
,
2JY8
,
5YPB
,
5YPG
,
6TGY
,
5YPC
,
5YPH
,
5YP8
,
6KHZ
,
6MJ7
,
2JY7
,
7R1O
,
5YPE
,
6JM4
,
4UF8
,
5YPF
,
5YPA
,
4MJS
,
4UF9
,
2K0B
,
6TH3
,
2KNV
,
1Q02
Interactors (59)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.978
31
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.97
25
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.967
21
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.953
18
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
0.951
16
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.948
17
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.901
8
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.894
11
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.888
10
IntAct:EBI-4399559 UBIQ
0.829
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.806
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.801
8
UniProt:Q14596 NBR1
2
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
NBR1 [cytosol]
(R-HSA-9665180)
0.775
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.771
11
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.728
9
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.725
6
UniProt:Q8IZQ1 WDFY3
0.709
7
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.688
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.67
18
UniProt:Q15038 DAZP2
0.666
4
UniProt:P54253 ATX1
0.666
4
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.666
4
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.666
5
UniProt:Q9BPW8 NIPS1
0.65
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.635
3
UniProt:P11473 VDR
2
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
VDR [nucleoplasm]
(R-HSA-375512)
0.591
4
UniProt:Q6IRU7
1
Cep78 [cytosol]
(R-MMU-380304)
0.564
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.558
7
UniProt:Q9UGJ0 PRKAG2
2
PRKAG2 [nucleoplasm]
(R-HSA-164130)
PRKAG2 [cytosol]
(R-HSA-200419)
0.556
3
UniProt:O14682 ENC1
0.556
7
UniProt:O14576-2 O145762
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:P34972 CNR2
1
CNR2 [plasma membrane]
(R-HSA-419372)
0.556
5
UniProt:P19544-6 WT1
0.556
3
UniProt:P12709
4
GPI [secretory granule lumen]
(R-SCE-6801495)
GPI [extracellular region]
(R-SCE-6806478)
GPI [ficolin-1-rich granule lumen]
(R-SCE-6801506)
GPI [cytosol]
(R-SCE-70468)
0.556
3
UniProt:A8K2U6 A8K2U6
0.556
3
IntAct:EBI-25830852 RZPDO839G03145
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
HSPA1A [cytosol]
(R-HSA-6792602)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
6
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q2V2M9 FHOD3
0.543
6
UniProt:Q2V2M9-4 FHOD3
0.543
4
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.543
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.537
3
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.537
4
UniProt:Q15334 L2GL1
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
3
UniProt:P16070 CD44
2
CD44 [secretory granule membrane]
(R-HSA-6804776)
CD44 [plasma membrane]
(R-HSA-1031688)
0.527
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.524
2
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.524
4
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.524
2
UniProt:P38182
12
ATG8 [cytosol]
(R-SCE-5205651)
ATG8 [cytosol]
(R-SCE-5205676)
ATG8 [cytosol]
(R-SCE-975521)
ATG8 [cytosol]
(R-SCE-5679223)
ATG8 [cytosol]
(R-SCE-5682696)
ATG8 [cytosol]
(R-SCE-5682674)
ATG8 [cytosol]
(R-SCE-5682653)
ATG8 [cytosol]
(R-SCE-5682681)
ATG8 [autophagosome membrane]
(R-SCE-5683634)
ATG8 [autophagosome membrane]
(R-SCE-5683638)
ATG8 [autophagosome membrane]
(R-SCE-5683640)
ATG8 [autophagosome membrane]
(R-SCE-5683641)
0.508
3
UniProt:P12504 VIF
0.499
2
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
UniProt:O70405
7
ULK1 [recycling endosome]
(R-MMU-8854761)
phospho-p-S758-ULK1 [cytosol]
(R-MMU-5672131)
phospho-p-S317,467,556,638,T575-ULK1 [cytosol]
(R-MMU-5673747)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-MMU-5675858)
phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-MMU-8948047)
ULK1 [mitochondrial outer membrane]
(R-MMU-8948145)
ULK1 [cytosol]
(R-MMU-1632847)
0.499
2
UniProt:Q9NX00 TM160
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
14
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