ub-KEAP1 [cytosol]

Stable Identifier
R-HSA-9766647
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Kelch-like ECH-associated protein 1, KEAP1_HUMAN, KLHL19, KIAA0132
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15983046 Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

Sun, Z, Zhang, DD, Hannink, M, Lieberman, MW, Habib, GM, Lo, SC

J Biol Chem 2005
External Reference Information
External Reference
Gene Names
KEAP1, INRF2, KIAA0132, KLHL19
Chain
chain:1-624
Other Identifiers
11716444_a_at
16868743
202417_PM_at
202417_at
35322_at
3850364
3850365
3850366
3850367
3850369
3850370
3850371
3850372
3850373
3850374
3850376
3850377
3850378
3850379
3850381
8034034
9817
A_23_P119141
D50922_at
GE57257
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006351
GO:0006355
GO:0006511
GO:0006914
GO:0008152
GO:0010506
GO:0016234
GO:0016567
GO:0030154
GO:0030163
GO:0030496
GO:0031463
GO:0032436
GO:0032991
GO:0034451
GO:0034599
GO:0036211
GO:0042802
GO:0042994
GO:0043226
GO:0043433
GO:0045604
GO:0048856
GO:0060090
GO:0061629
GO:0070887
GO:0071353
GO:0097718
GO:0098772
GO:0140416
GO:1990756
HMNXSV003035494
ILMN_1711787
ILMN_2410771
ILMN_2410772
PH_hs_0003698
TC19001166.hg
g6912451_3p_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (73)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q16236 NFE2L2  13 0.975 37
 UniProt:Q13501 SQSTM1  7 0.962 19
 UniProt:Q9NY33 DPP3  1 0.874 10
 UniProt:Q13257 MAD2L1  2 0.834 8
 UniProt:P62495 ETF1  3 0.834 8
 UniProt:Q9BRX9 WDR83  1 0.781 7
 UniProt:Q86YC2 PALB2  20 0.742 5
 UniProt:Q96TA1 NIBA2      0.726 9
 UniProt:Q6P9E2 Q6P9E2      0.718 6
 UniProt:P06454-2 PTMA      0.718 6
 UniProt:Q6P1L5 F117B      0.718 6
 UniProt:P54619 PRKAG1  2 0.718 6
 UniProt:P62310 LSM3  2 0.718 6
 UniProt:Q14494 NF2L1      0.704 28
 UniProt:O95198 KLHL2  1 0.703 5
 UniProt:Q13618 CUL3  3 0.666 5
 UniProt:P02724 GYPA  1 0.666 4
 UniProt:Q9NPC3 CIP1      0.666 4
 UniProt:O14525-2 ASTN1      0.618 4
 UniProt:O14920 IKBKB  3 0.61 6
 UniProt:Q9Y3Q8 T22D4      0.608 3
 UniProt:P45381 ASPA  1 0.601 4
 UniProt:Q04206 RELA  6 0.592 4
 UniProt:O95166 GABARAP  3 0.59 5
 UniProt:Q9BTE3 MCMBP      0.564 2
 UniProt:Q96HS1 PGAM5      0.564 3
 UniProt:Q7Z699 SPRED1  2 0.556 3
 UniProt:B8Q183 B8Q183      0.556 4
 UniProt:P68400 CSNK2A1  2 0.556 3
 UniProt:P02458-1 COL2A1      0.556 3
 UniProt:Q2NKX9 CB068      0.556 3
 UniProt:P05107 ITGB2  4 0.556 3
 UniProt:A9UGY9 A9UGY9      0.556 3
 UniProt:Q14440 Q14440      0.556 3
 UniProt:P05362 ICAM1  1 0.556 3
 UniProt:P58317 ZN121      0.556 3
 UniProt:Q9BYX4 IFIH1  3 0.556 3
 UniProt:Q6P6B1 ERIC5      0.556 3
 UniProt:Q9P202 WHRN  1 0.556 3
 UniProt:Q96HA8 NTAQ1      0.556 3
 IntAct:EBI-25847655 CCSB      0.556 3
 UniProt:O60336 MABP1      0.556 3
 UniProt:Q9NX65 ZSCAN32  1 0.556 3
 UniProt:A0A0C4DFT7 A0A0C4DFT7      0.556 3
 UniProt:Q9BWT7 CAR10      0.556 3
 UniProt:Q49AR9 Q49AR9      0.556 3
 UniProt:Q8TDV0 GP151      0.556 3
 UniProt:Q9UKX7 NUP50  1 0.556 3
 UniProt:Q8N573-5 OXR1      0.556 3
 UniProt:Q9NZJ9 NUDT4  1 0.556 3
 UniProt:Q9BTE3-2 MCMBP      0.556 3
 UniProt:Q9UH77 KLHL3  1 0.556 3
 UniProt:Q96GM5 SMARCD1  1 0.556 3
 UniProt:P17709  7 0.556 3
 UniProt:P38109 ATG42      0.556 3
 UniProt:Q4KMZ1 IQCC      0.556 3
 UniProt:P28799 GRN  2 0.556 3
 UniProt:Q8N4I8 Q8N4I8      0.556 3
 UniProt:Q9P0N9 TBC1D7  1 0.556 3
 UniProt:Q9NX09 DDIT4  1 0.556 3
 UniProt:O76024 WFS1  3 0.556 3
 UniProt:P02452 COL1A1  20 0.556 3
 UniProt:Q9H1Y0 ATG5  3 0.556 3
 UniProt:Q9UGK3 STAP2  2 0.556 3
 UniProt:Q96JC9 EAF1  1 0.556 3
 UniProt:Q15149 PLEC  3 0.544 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.527 2
 UniProt:P54274 TERF1  1 0.508 2
 UniProt:O88351  2 0.508 2
 UniProt:P15314  1 0.499 2
 UniProt:P58004 SESN2  1 0.499 3
 UniProt:Q5JTC6 AMER1  5 0.499 2
 UniProt:Q9UF56 FBXL17  1 0.462 7
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