Factor H binds to C3b

Stable Identifier
R-HSA-976768
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Factor H (CFH) regulates the alternative pathway C3 convertase C3bBb and its C3b component both in plasma and at host cell surfaces. FH binds to plasma C3b, making it unavailable, and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b.
Literature References
PubMed ID Title Journal Year
1067618 Control of the amplification convertase of complement by the plasma protein beta1H

Weiler, JM, Fearon, DT, Daha, MR, Austen, KF

Proc Natl Acad Sci U S A 1976
301546 Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

Schreiber, RD, Pangburn, MK, Muller-Eberhard, HJ

J Exp Med 1977
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