Reactome | LENG1 [nucleoplasm]

LENG1 [nucleoplasm]

Stable Identifier

R-HSA-9769590

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Leukocyte receptor cluster member 1, LENG1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96N21 AP4AT

Expand all

External Reference Information

External Reference

UniProt:Q96BZ8 LENG1

Gene Names

LENG1

Chain

chain:1-264

Reference Genes

BioGPS Gene:79165 LENG1

COSMIC (genes):LENG1 LENG1

CTD Gene:79165 LENG1

dbSNP Gene:79165 LENG1

ENSEMBL:ENSG00000105617 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000105617.4 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000275935.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000276628.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000276774.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000276959.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000277457.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000277808.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000278257.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000278426.1 LENG1

ENSEMBL_homo_sapiens_GENE:ENSG00000278516.1 LENG1

HGNC:15502 LENG1

KEGG Gene (Homo sapiens):79165 LENG1

Monarch:79165 LENG1

NCBI Gene:79165 LENG1

UCSC:Q96BZ8 LENG1

Reference Transcript

RefSeq:NM_024316.2 LENG1

Other Identifiers

11734157_a_at

16875290

232018_PM_at

232018_at

3870521

3870522

3870523

3870524

3870525

3870526

3870527

79165

8039139

84668_at

A_23_P208523

GE530373

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0008150

GO:0043226

HMNXSV003054694

Hs.172407.0.S1_3p_at

ILMN_1679238

TC19001835.hg

Participates

as an input of

Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

as a component of

Spliceosomal P complex [nucleoplasm] (Homo sapiens)

Inferred To

LENG1 [nucleoplasm] (Bos taurus)

LENG1 [nucleoplasm] (Caenorhabditis elegans)

LENG1 [nucleoplasm] (Canis familiaris)

LENG1 [nucleoplasm] (Dictyostelium discoideum)

LENG1 [nucleoplasm] (Sus scrofa)

leng1 [nucleoplasm] (Danio rerio)

leng1 [nucleoplasm] (Xenopus tropicalis)

Dmel\CG12818 [nucleoplasm] (Drosophila melanogaster)

Leng1 [nucleoplasm] (Mus musculus)

Leng1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of LENG1 [nucleoplasm] (Gallus gallus)

Ghost homologue of LENG1 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of LENG1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_077292.2

OpenTargets

ENSG00000105617

HPA

ENSG00000105617-LENG1

GeneCards

Q96BZ8

Ensembl

ENSG00000276959, ENST00000617592, ENSG00000277457, ENST00000616103, ENSG00000276774, ENSG00000277808, ENST00000621285, ENSP00000481252, ENSP00000222224, ENST00000614037, ENST00000619669, ENST00000222224, ENST00000616816, ENSP00000481079, ENST00000613622, ENST00000610998, ENSP00000477607, ENSG00000278257, ENSG00000278516, ENST00000621927, ENSG00000276628, ENSG00000275935, ENSP00000483164, ENSP00000481386, ENSP00000479538, ENSP00000480516, ENSP00000478485, ENSP00000481948, ENSG00000278426, ENSG00000105617

PRO

Q96BZ8

Pharos - Targets

Q96BZ8

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.795	8
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.781	7
UniProt:O95751 LDOC1			0.781	8
UniProt:Q9HAT0 ROPN1	1	ROPN1 [cytosol] (R-HSA-5667048)	0.781	8
UniProt:Q9UJV3-2 MID2			0.718	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q01850 CDR2			0.718	6
UniProt:A1L4K1 FSD2			0.718	6
UniProt:Q9BYV2 TRI54			0.718	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.718	6
UniProt:Q04864-2 REL			0.666	4
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.666	4
UniProt:P61970 NTF2			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q8WW34 TM239			0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q96KG9-4 SCYL1			0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H0C1 ZMY12			0.556	3
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q8WXK4-2 Q8WXK42			0.556	3
UniProt:Q5VU43 MYOME			0.556	3
UniProt:Q9P2M1 LR2BP			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.556	3
UniProt:Q9ULR0-1 Q9ULR01			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q5T124-6 UBXN11			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:Q9NWQ9 CN119			0.556	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q99687-3 Q996873			0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q86X02 CDR2L			0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q8N8X9 MB213			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:O60447 EVI5			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:P36406 TRI23			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) CARD9 [plasma membrane] (R-HSA-5607662) p-T231-CARD9 [plasma membrane] (R-HSA-5607623)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q6AZZ1 TRIM68	1	TRIM68 [cytosol] (R-HSA-5624350)	0.527	2
UniProt:Q96DF8 ESS2			0.527	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	2
UniProt:P14079 TAX			0.488	2

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