Reactome | NKAP [nucleoplasm]

NKAP [nucleoplasm]

Stable Identifier

R-HSA-9769602

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NF-kappa-B-activating protein, NKAP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8N5F7 NKAP

Gene Names

NKAP

Chain

chain:1-415

Reference Genes

BioGPS Gene:79576 NKAP

COSMIC (genes):NKAP NKAP

CTD Gene:79576 NKAP

dbSNP Gene:79576 NKAP

ENSEMBL:ENSG00000101882 NKAP

HGNC:29873 NKAP

KEGG:hsa:79576 NKAP

Monarch:79576 NKAP

NCBI Gene:79576 NKAP

OMIM:300766 NKAP

UCSC:Q8N5F7 NKAP

Reference Transcript

RefSeq:NM_024528.3 NKAP

Other Identifiers

11755063_a_at

17113655

17113658

223439_PM_at

223439_at

228493_PM_at

228493_at

4019612

4019613

4019614

4019615

4019616

4019617

4019618

4019620

4019621

4019622

4019623

4019624

4019625

4019627

4019628

4019629

4019630

4019631

4019632

4019633

4019634

4019776

46111_f_at

46112_r_at

59075_at

59077_at

67426_at

72339_at

79576

8174737

ADDON001111.hg

A_21_P0006460

A_21_P0014740

A_23_P62276

GE83769

GE87703

GO:0000122

GO:0002376

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0007219

GO:0030097

GO:0030154

GO:0030851

GO:0031490

GO:0033077

GO:0035019

GO:0043226

GO:0045892

GO:0046638

GO:0048856

GO:0071425

HMNXSV003003608

HMNXSV003029972

HMNXSV003030544

HMNXSV003043120

Hs.184993.0.A1_3p_at

ILMN_1675359

ILMN_2067980

PH_hs_0028420

TC0X001317.hg

TC0X001318.hg

TC0X002210.hg

g12654240_3p_at

p17071

Participates

as an input of

Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

as a component of

Spliceosomal P complex [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of NKAP [nucleoplasm] (Rattus norvegicus)

Nkap [nucleoplasm] (Mus musculus)

Nkap [nucleoplasm] (Rattus norvegicus)

NKAPL [nucleoplasm] (Gallus gallus)

Ghost homologue of NKAP [nucleoplasm] (Schizosaccharomyces pombe)

nkap [nucleoplasm] (Danio rerio)

nkap [nucleoplasm] (Xenopus tropicalis)

NKAP [nucleoplasm] (Bos taurus)

NKAP [nucleoplasm] (Canis familiaris)

NKAP [nucleoplasm] (Dictyostelium discoideum)

NKAP [nucleoplasm] (Drosophila melanogaster)

NKAP [nucleoplasm] (Plasmodium falciparum)

NKAP [nucleoplasm] (Sus scrofa)

let-504 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_078804.2

ENSEMBL

ENSP00000360464, ENST00000371410

OpenTargets

ENSG00000101882

HPA

ENSG00000101882-NKAP

PRO

Q8N5F7

Pharos - Targets

Q8N5F7

GlyGen

Q8N5F7

PDB

6QDV, 7W5B, 8C6J

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.725	7
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.716	5
UniProt:O75052 CAPON			0.659	5
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.643	5
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.643	5
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.632	3
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.564	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.556	3
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.547	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.527	3
UniProt:Q5M9Q1 NKAPL			0.527	4
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.527	5
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.508	2
UniProt:Q9Y388 RBMX2	1	RBMX2 [nucleoplasm] (R-HSA-9769535)	0.508	2
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.508	2
UniProt:O75400 PRPF40A	1	PRPF40A [nucleoplasm] (R-HSA-8867890)	0.508	2
UniProt:Q9Y3M2 CBY1	3	CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [nucleoplasm] (R-HSA-3769356) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.508	2
UniProt:P03410 TAX			0.488	2

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