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Go!
PRL [extracellular region]
Stable Identifier
R-HSA-976984
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Prolactin, PRL_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR activation (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR binds SCF beta-TrCP complex (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR binds SHP2 (PTPN11) (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR is phosphorylated at Ser-349 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Prolactin receptor is internalized (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
SH2B binds JAK2 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
SHP2 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of PRLR (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Prolactin amyloid fibril [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Prolactin amyloid fibril [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Amyloid precursor proteins form ordered fibrils (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Prolactin amyloid fibril [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
Amyloid fibril monomers [extracellular region] (Homo sapiens)
Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
PRL [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01236 PRL
Gene Names
PRL
Chain
signal peptide:1-28, chain:29-227
Reference Genes
BioGPS Gene:5617 PRL
COSMIC (genes):PRL PRL
CTD Gene:5617 PRL
dbSNP Gene:5617 PRL
ENSEMBL:ENSG00000172179 PRL
ENSEMBL_homo_sapiens_GENE:ENSG00000172179.13 PRL
HGNC:9445 PRL
KEGG Gene (Homo sapiens):5617 PRL
Monarch:5617 PRL
NCBI Gene:5617 PRL
OMIM:176760 PRL
Reference Transcript
RefSeq:NM_000948.5 PRL
RefSeq:NM_001163558.2 PRL
Other Identifiers
11715754_at
17016089
205445_PM_at
205445_at
2945130
2945131
2945132
2945133
2945135
2945136
2945137
2945139
2945140
2945143
2945144
5617
8124185
878_s_at
A_32_P65616
GE59612
GO:0001937
GO:0005148
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0006351
GO:0006355
GO:0007165
GO:0007166
GO:0007565
GO:0007595
GO:0008284
GO:0016525
GO:0022414
GO:0023052
GO:0030879
GO:0031410
GO:0031667
GO:0031904
GO:0031982
GO:0038161
GO:0043123
GO:0043226
GO:0046427
GO:0046872
GO:0048018
GO:0048856
GO:0098772
GO:1902895
GO:1903489
HMNXSV003045354
ILMN_1809352
M29386_s_at
PH_hs_0000254
PH_hs_0035318
TC06001320.hg
X00368_xpt2_at
X00540_at
g4506104_3p_at
Participates
as a member of
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
as a repeated unit of
Prolactin amyloid fibril [extracellular region] (Homo sapiens)
Other forms of this molecule
PRL [endosome lumen]
Inferred To
zgc:110500 [extracellular region]
(Danio rerio)
Prl [extracellular region]
(Mus musculus)
Prl [extracellular region]
(Rattus norvegicus)
prl.1 [extracellular region]
(Xenopus tropicalis)
PRL [extracellular region]
(Bos taurus)
PRL [extracellular region]
(Canis familiaris)
PRL [extracellular region]
(Gallus gallus)
PRL [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001157030.1
,
NP_000939.1
OpenTargets
ENSG00000172179
GeneCards
P01236
HPA
ENSG00000172179-PRL
Ensembl
ENSP00000302150
,
ENST00000306482
,
ENSG00000172179
PRO
P01236
Pharos - Targets
P01236
PDB
3NCC
,
3NCE
,
3N06
,
3MZG
,
3NCF
,
3D48
,
3NPZ
,
2Q98
,
3N0P
,
1RW5
,
3NCB
,
3EW3
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