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GEM [plasma membrane]
Stable Identifier
R-HSA-9769962
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GTP-binding protein GEM, GEM_HUMAN, GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR, KIR
Locations in the PathwayBrowser for interactor UniProt:Q8ND90 PNMA1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
NPAS4 regulates expression of target genes (Homo sapiens)
NPAS4 stimulates GEM gene expression (Homo sapiens)
GEM [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55040 GEM
Gene Names
GEM, KIR
Chain
chain:1-296
Reference Genes
BioGPS Gene:2669 GEM
COSMIC (genes):GEM GEM
CTD Gene:2669 GEM
dbSNP Gene:2669 GEM
ENSEMBL:ENSG00000164949 GEM
ENSEMBL_homo_sapiens_GENE:ENSG00000164949.8 GEM
HGNC:4234 GEM
KEGG Gene (Homo sapiens):2669 GEM
Monarch:2669 GEM
NCBI Gene:2669 GEM
OMIM:600164 GEM
UCSC:P55040 GEM
Reference Transcript
RefSeq:NM_005261.3 GEM
RefSeq:NM_181702.2 GEM
Other Identifiers
11720558_a_at
17079210
204472_PM_at
204472_at
2669
3144935
3144936
3144937
3144938
3144941
3144948
3144949
3144953
3144954
37279_at
8151816
A_23_P257043
GE58914
GO:0000166
GO:0000278
GO:0000287
GO:0002376
GO:0003824
GO:0003924
GO:0005246
GO:0005515
GO:0005516
GO:0005525
GO:0005634
GO:0005856
GO:0005886
GO:0006955
GO:0007059
GO:0007165
GO:0007166
GO:0009898
GO:0016020
GO:0016787
GO:0019003
GO:0023052
GO:0030496
GO:0043226
GO:0051233
GO:0051276
GO:0051310
GO:0055085
GO:0072686
GO:0098772
GO:1901842
HMNXSV003008060
ILMN_1677092
ILMN_1678968
ILMN_2367883
PH_hs_0004561
TC08001432.hg
U10550_at
g4885262_3p_at
g4885262_3p_x_at
Participates
as an output of
NPAS4 stimulates GEM gene expression (Homo sapiens)
Cross References
RefSeq
NP_859053.1
,
NP_005252.1
OpenTargets
ENSG00000164949
GeneCards
P55040
HPA
ENSG00000164949-GEM
Ensembl
ENST00000396194
,
ENSP00000379497
,
ENSG00000164949
,
ENST00000297596
,
ENSP00000297596
PRO
P55040
Pharos - Targets
P55040
HMDB Protein
HMDBP11454
PDB
2CJW
,
2HT6
,
2G3Y
Interactors (116)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P36406 TRI23
0.817
7
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.781
7
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.742
5
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.718
6
UniProt:O43865 AHCYL1
1
AHCYL1 [endoplasmic reticulum membrane]
(R-HSA-5215973)
0.718
8
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:Q9UKT9 IKZF3
0.718
8
UniProt:Q7L273 KCTD9
0.718
6
UniProt:Q9BRK4 LZTS2
0.718
6
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.718
6
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.718
6
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.718
6
UniProt:Q5JR59-3 MTUS2
0.666
6
UniProt:Q9UJV3-2 MID2
0.666
4
UniProt:P54284 CACNB3
2
CACNB3 [cytosol]
(R-HSA-210401)
CACNB3 [plasma membrane]
(R-HSA-532201)
0.601
8
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.597
4
UniProt:Q02641 CACNB1
2
CACNB1 [cytosol]
(R-HSA-210493)
CACNB1 [plasma membrane]
(R-HSA-532197)
0.589
3
UniProt:Q9H079 KTBL1
0.556
5
UniProt:Q8WVV4-1 POF1B
0.556
3
UniProt:Q9NWS0 PIHD1
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:O76013-2 KRT36
0.556
3
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:Q86Z20 CC125
0.556
3
UniProt:Q8IYA8 IHO1
0.556
3
UniProt:Q59EK9 RUN3A
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q9UDY6-2 TRIM10
0.556
3
UniProt:Q96R06 SPAG5
0.556
3
IntAct:EBI-10171556 147700
0.556
3
UniProt:P17568 NDUFB7
1
NDUFB7 [mitochondrial inner membrane]
(R-HSA-59940)
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:O60504 SORBS3
1
SORBS3 [cytosol]
(R-HSA-445805)
0.556
3
UniProt:Q9P2M1 LR2BP
0.556
3
UniProt:Q96MW5 COG8
2
COG8 [trans-Golgi network membrane]
(R-HSA-6813875)
COG8 [Golgi membrane]
(R-HSA-6808728)
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:Q9UK41-2 VPS28
0.556
3
UniProt:O15535 ZSC9
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9NQX0 PRDM6
0.556
3
UniProt:O75031 HSF2B
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q9UDW3 ZMAT5
1
ZMAT5 [nucleoplasm]
(R-HSA-6787850)
0.556
3
UniProt:Q86U28 ISCA2
1
ISCA2 [mitochondrial matrix]
(R-HSA-5691207)
0.556
3
UniProt:Q9HD26-2 GOPC
0.556
3
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.556
3
UniProt:Q8NDD1-6 Q8NDD16
0.556
3
UniProt:P02538 KRT6A
1
KRT6A [cytosol]
(R-HSA-6809654)
0.556
3
UniProt:P78385 KRT83
1
KRT83 [cytosol]
(R-HSA-6809636)
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q05D60 DEUP1
0.556
6
UniProt:Q9UPG8 PLAL2
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q1MX18 INSC
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:O43482 OIP5
1
OIP5 [nucleoplasm]
(R-HSA-606286)
0.556
3
UniProt:Q14696 MESD
0.556
3
UniProt:P15173 MYOG
1
MYOG [nucleoplasm]
(R-HSA-445160)
0.556
3
UniProt:A0A0C4DFN3 A0A0C4DFN3
0.556
3
UniProt:Q4VC12 MSS51
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.556
3
UniProt:O60641-3 SNAP91
0.556
3
UniProt:Q8N2N9-4 ANKRD36B
0.556
3
UniProt:Q6PF18 MORN3
0.556
3
UniProt:P0C7X2 ZNF688
1
ZNF688 [nucleoplasm]
(R-HSA-2248884)
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q9H707 ZNF552
1
ZNF552 [nucleoplasm]
(R-HSA-1973877)
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q6DHY5 TBC3G
0.556
3
UniProt:Q495M9 USH1G
1
USH1G [cytosol]
(R-HSA-9658869)
0.556
3
UniProt:Q8NFT6-2 DBF4B
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.556
3
UniProt:Q8WXK1 ASB15
1
ASB15 [cytosol]
(R-HSA-975426)
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
UniProt:Q9NZC7-5 WWOX
0.556
3
UniProt:Q01850 CDR2
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.556
3
UniProt:Q96PF1 TGM7
0.556
3
UniProt:Q9NWH7-2 Q9NWH72
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q9Y2D8 ADIP
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
1
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q9NQZ6 ZC4H2
0.556
3
UniProt:Q6QNY1 BL1S2
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:P48059-3 LIMS1
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q6NX45 ZNF774
1
ZNF774 [nucleoplasm]
(R-HSA-3110232)
0.556
3
UniProt:Q13049 TRIM32
1
TRIM32 [cytosol]
(R-HSA-976030)
0.556
3
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:Q9BUH8 BEGAIN
1
BEGAIN [cytosol]
(R-HSA-6794250)
0.556
5
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:P27884 CAC1A
0.499
2
UniProt:P54287 Cacnb3
2
Voltage-dependent L-type calcium channel subunit beta-3 [plasma membrane]
(R-RNO-446472)
Cacnb3 [cytosol]
(R-RNO-210401)
0.499
2
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