Serine biosynthesis

Stable Identifier
R-HSA-977347
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Serine biosynthesis
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L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004).
Literature References
PubMed ID Title Journal Year
15021249 Serine-deficiency syndromes

Klomp, LW, de Koning, TJ

Curr Opin Neurol 2004
Participants
Events
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Event Information
Go Biological Process
L-serine biosynthetic process (0006564)
Orthologous Events
Serine biosynthesis (Bos taurus)
Serine biosynthesis (Caenorhabditis elegans)
Serine biosynthesis (Canis familiaris)
Serine biosynthesis (Danio rerio)
Serine biosynthesis (Dictyostelium discoideum)
Serine biosynthesis (Drosophila melanogaster)
Serine biosynthesis (Gallus gallus)
Serine biosynthesis (Mus musculus)
Serine biosynthesis (Rattus norvegicus)
Serine biosynthesis (Saccharomyces cerevisiae)
Serine biosynthesis (Schizosaccharomyces pombe)
Serine biosynthesis (Sus scrofa)
Serine biosynthesis (Xenopus tropicalis)
Authored
Stephan, R  (2010-10-16)
Reviewed
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2010-10-18)
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