Reactome | CD46 [plasma membrane]

CD46 [plasma membrane]

Stable Identifier

R-HSA-977362

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Membrane cofactor protein, MCP_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P78504 JAG1

Expand all

External Reference Information

External Reference

UniProt:P15529 CD46

Gene Names

CD46, MCP, MIC10

Chain

signal peptide:1-34, chain:35-392

Reference Genes

BioGPS Gene:4179 CD46

COSMIC (genes):CD46 CD46

CTD Gene:4179 CD46

dbSNP Gene:4179 CD46

ENSEMBL:ENSG00000117335 CD46

HGNC:6953 CD46

KEGG Gene (Homo sapiens):4179 CD46

Monarch:4179 CD46

NCBI Gene:4179 CD46

OMIM:120920 CD46

UCSC:P15529 CD46

Reference Transcript

Other Identifiers

0005670408

11718970_a_at

11718971_x_at

11720595_a_at

11735060_a_at

11735681_x_at

11742219_a_at

11742220_x_at

11743903_a_at

11751532_x_at

11751549_a_at

11751550_x_at

11755715_x_at

16676893

207549_PM_x_at

207549_x_at

208783_PM_s_at

208783_s_at

211574_PM_s_at

211574_s_at

2377431

2377433

2377455

2377456

2377457

2377458

2377459

2377462

2377463

2377464

2377466

2377471

2377472

2377474

2377476

2377481

2377485

2377488

2377490

2377491

2377497

2377498

2377503

2377504

2377505

2377506

2377507

2377508

38441_s_at

4179

7909400

A_23_P201758

A_23_P35230

A_24_P282597

GE59843

GO:0000003

GO:0001618

GO:0002079

GO:0002250

GO:0002376

GO:0002456

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0005925

GO:0006950

GO:0006958

GO:0007155

GO:0007165

GO:0007338

GO:0008150

GO:0008283

GO:0008593

GO:0009986

GO:0010628

GO:0010629

GO:0016020

GO:0016021

GO:0030154

GO:0031410

GO:0032733

GO:0035581

GO:0038023

GO:0042102

GO:0043226

GO:0043382

GO:0044403

GO:0045087

GO:0045296

GO:0045591

GO:0045959

GO:0046718

GO:0048856

GO:0070062

GO:0071636

HMNXSV003057394

Hs.83532.1.A2_3p_a_at

ILMN_1815689

ILMN_2307740

ILMN_2307744

PH_hs_0004767

TC01001741.hg

X59405_at

g11321566_3p_a_at

Participates

as an input of

as a member of

CD46, CR1 [plasma membrane] (Homo sapiens)

as a component of

Inferred To

CT26106 [plasma membrane] (Drosophila melanogaster)

Hasp [plasma membrane] (Drosophila melanogaster)

LOC609365 [plasma membrane] (Canis familiaris)

fw [plasma membrane] (Drosophila melanogaster)

CD46 [plasma membrane] (Bos taurus)

CD46 [plasma membrane] (Sus scrofa)

sele [plasma membrane] (Danio rerio)

hig [plasma membrane] (Drosophila melanogaster)

C4BPA [plasma membrane] (Gallus gallus)

Homologues of CD46 [plasma membrane] (Danio rerio)

Homologues of CD46 [plasma membrane] (Drosophila melanogaster)

Homologues of CD46 [plasma membrane] (Xenopus tropicalis)

Cd46 [plasma membrane] (Mus musculus)

Cd46 [plasma membrane] (Rattus norvegicus)

svep1 [plasma membrane] (Danio rerio)

arc3 [plasma membrane] (Xenopus tropicalis)

c4bpa [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_758871.1, NP_758860.1, XP_011507866.1, NP_758869.1, XP_016856798.1, NP_758861.1, XP_016856799.1, NP_722548.1, NP_002380.3, XP_011507865.1, NP_758862.1, NP_758863.1, XP_016856797.1

OpenTargets

ENSG00000117335

GeneCards

P15529

HPA

ENSG00000117335-CD46

Ensembl

ENST00000367047, ENST00000322875, ENST00000354848, ENSP00000356009, ENSP00000350893, ENSP00000353342, ENSP00000350346, ENSG00000117335, ENSP00000356008, ENST00000367042, ENST00000358170, ENST00000322918, ENSP00000356014, ENSP00000313875, ENST00000367041, ENST00000360212, ENSP00000314664, ENSP00000346912, ENST00000357714, ENST00000480003, ENSP00000418471

PRO

P15529

Pharos - Targets

P15529

Orphanet

15416

PDB

1CKL, 2O39, 3INB, 5FO8, 3O8E, 3L89

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-12735745 C3B			0.761	4
UniProt:P78504 JAG1	2	Ub-JAG1 [plasma membrane] (R-HSA-9013079) JAG1 [plasma membrane] (R-HSA-157098)	0.632	5
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.623	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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