Reactome | ZC3H12A [nucleoplasm]

ZC3H12A [nucleoplasm]

Stable Identifier

R-HSA-9774235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Endoribonuclease ZC3H12A, MCPIP, MCPIP1, Monocyte chemotactic protein-induced protein 1, MCP-induced protein 1, MCPIP-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q5D1E8 ZC3H12A

Gene Names

ZC3H12A, MCPIP, MCPIP1

Chain

chain:1-599

Reference Genes

BioGPS Gene:80149 ZC3H12A

COSMIC (genes):ZC3H12A ZC3H12A

CTD Gene:80149 ZC3H12A

dbSNP Gene:80149 ZC3H12A

ENSEMBL:ENSG00000163874 ZC3H12A

HGNC:26259 ZC3H12A

KEGG:hsa:80149 ZC3H12A

Monarch:80149 ZC3H12A

NCBI Gene:80149 ZC3H12A

OMIM:610562 ZC3H12A

UCSC:Q5D1E8 ZC3H12A

Reference Transcript

Other Identifiers

11755079_a_at

16662623

218810_PM_at

218810_at

2330688

2330689

2330690

2330691

2330692

2330694

2330695

2330696

2330697

2330698

2330699

2330700

2330701

2330702

2330703

2330704

48766_at

7900146

80149

A_23_P326160

A_33_P3214720

GE87290

GO:0000184

GO:0000932

GO:0001525

GO:0001933

GO:0002230

GO:0002376

GO:0002757

GO:0003677

GO:0003682

GO:0003723

GO:0003729

GO:0003730

GO:0003824

GO:0004518

GO:0004519

GO:0004521

GO:0004532

GO:0004540

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005791

GO:0005856

GO:0006355

GO:0006402

GO:0006915

GO:0006954

GO:0006974

GO:0007399

GO:0010468

GO:0010508

GO:0010587

GO:0010595

GO:0010628

GO:0010629

GO:0010656

GO:0010884

GO:0012501

GO:0016020

GO:0016071

GO:0016579

GO:0016787

GO:0030154

GO:0030867

GO:0032088

GO:0032689

GO:0032691

GO:0032715

GO:0032720

GO:0032991

GO:0034599

GO:0035198

GO:0035613

GO:0035925

GO:0036464

GO:0042149

GO:0042307

GO:0043022

GO:0043031

GO:0043124

GO:0043226

GO:0044828

GO:0045019

GO:0045600

GO:0045766

GO:0045944

GO:0046872

GO:0048856

GO:0050852

GO:0051259

GO:0051607

GO:0055118

GO:0061014

GO:0061158

GO:0065003

GO:0071222

GO:0071347

GO:0071356

GO:0098542

GO:0098586

GO:0140096

GO:0140098

GO:1900016

GO:1900119

GO:1900745

GO:1901223

GO:1903003

GO:1903936

GO:1904637

GO:1990869

GO:2000320

GO:2000379

GO:2000627

HMNXSV003007878

HMNXSV003012699

HMNXSV003047725

ILMN_1672295

PH_hs_0014957

TC01000474.hg

g13376631_3p_at

Participates

as a component of

ZC3H12A:CDH19 gene [nucleoplasm] (Homo sapiens)

as an input of

ZC3H12A binds CDH19 gene promoter (Homo sapiens)

Inferred To

mps-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of ZC3H12A [nucleoplasm] (Caenorhabditis elegans)

Homologues of ZC3H12A [nucleoplasm] (Drosophila melanogaster)

ZC3H12A [nucleoplasm] (Bos taurus)

ZC3H12A [nucleoplasm] (Caenorhabditis elegans)

ZC3H12A [nucleoplasm] (Canis familiaris)

ZC3H12A [nucleoplasm] (Gallus gallus)

ZC3H12A [nucleoplasm] (Mus musculus)

ZC3H12A [nucleoplasm] (Rattus norvegicus)

ZC3H12A [nucleoplasm] (Sus scrofa)

rde-8 [nucleoplasm] (Caenorhabditis elegans)

nyn-3 [nucleoplasm] (Caenorhabditis elegans)

CG13588 [nucleoplasm] (Drosophila melanogaster)

Regnase-1 [nucleoplasm] (Drosophila melanogaster)

zc3h12a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001310479.1, NP_079355.2

ENSEMBL

ENST00000373087, ENSP00000362179

OpenTargets

ENSG00000163874

HPA

ENSG00000163874-ZC3H12A

PRO

Q5D1E8

Pharos - Targets

Q5D1E8

HMDB Protein

HMDBP13852

PDB

3V33, 3V34, 3V32

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.718	6
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.667	3
UniProt:Q9NZD4 AHSP			0.666	4
UniProt:Q14694 USP10	3	USP10 [cytosol] (R-HSA-6782974) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [nucleoplasm] (R-HSA-3222218)	0.558	5
UniProt:P20095 PRP2			0.556	3
UniProt:P59910 DJB13			0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:Q02793 SKI8	2	SKI8 [nucleoplasm] (R-SCE-8866696) SKI8 [cytosol] (R-SCE-8931534)	0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.524	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.508	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.499	2

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