Reactome | H2AFX [extracellular region]

H2AFX [extracellular region]

Stable Identifier

R-HSA-977583

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Histone H2A.x, H2a/x

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Serum amyloid P binds DNA and chromatin (Homo sapiens)
    - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
      - Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2A [extracellular region] (Homo sapiens)
        
        H2AFX [extracellular region] (Homo sapiens)
    - Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
      - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
        
        Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2A [extracellular region] (Homo sapiens)
        
        H2AFX [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16104 H2AFX

Gene Names

H2AFX, H2AX

Chain

initiator methionine:, chain:2-143

Reference Genes

BioGPS Gene:3014 H2AFX

COSMIC (genes):H2AFX H2AFX

CTD Gene:3014 H2AFX

dbSNP Gene:3014 H2AFX

ENSEMBL:ENSG00000188486 H2AFX

HGNC:4739 H2AFX

KEGG:hsa:3014 H2AFX

Monarch:3014 H2AFX

NCBI Gene:3014 H2AFX

OMIM:601772 H2AFX

UCSC:P16104 H2AFX

Reference Transcript

RefSeq:NM_002105.2 H2AFX

Other Identifiers

11754243_a_at

16745236

205436_PM_s_at

205436_s_at

212525_3p_s_at

212525_PM_s_at

212525_s_at

3014

3394184

3394185

3394186

3394187

3394188

3394189

3394190

40195_at

7952179

A_24_P38895

GE59719

GO:0000077

GO:0000228

GO:0000724

GO:0000781

GO:0000785

GO:0000786

GO:0000794

GO:0001673

GO:0001741

GO:0003677

GO:0003684

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005813

GO:0005815

GO:0006281

GO:0006302

GO:0006310

GO:0006325

GO:0006334

GO:0006974

GO:0007283

GO:0010212

GO:0016607

GO:0019899

GO:0021987

GO:0022414

GO:0030527

GO:0031492

GO:0031507

GO:0035861

GO:0042393

GO:0043226

GO:0043229

GO:0045739

GO:0046982

GO:0048856

GO:0051321

GO:0060090

GO:0065003

GO:0070062

GO:0071480

GO:0090398

GO:0090734

GO:0140463

GO:1990166

HMNXSV003055476

Hs.147097.1.A1_3p_a_at

ILMN_1785756

ILMN_2200331

PH_hs_0008797

PH_hs_0040597

TC11002362.hg

X14850_at

g4504252_3p_a_at

Participates

as a candidate of

Histone H2A [extracellular region] (Homo sapiens)

Other forms of this molecule

H2AFX [nucleoplasm]

p-Y143-H2AFX [nucleoplasm]

p-S140,Y143-H2AFX [nucleoplasm]

p-S140-H2AFX [nucleoplasm]

K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]

Me2sR4-H2AFX [nucleoplasm]

Cross References

RefSeq

NP_002096.1

OpenTargets

ENSG00000188486

ENSEMBL

ENST00000375167, ENST00000530167, ENSP00000434024, ENSP00000364310

HPA

ENSG00000188486-H2AX

PRO

P16104

Pharos - Targets

P16104

GlyGen

P16104

PDB

6K1J, 6K1K, 3SZM, 6ZWK, 2DYP, 1YDP, 7YQK, 2D31, 2AZM, 3U3Z, 6K1I, 3SHV, 3SQD

Interactors (86)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.965	21
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.859	14
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.848	7
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.845	12
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.809	7
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.793	6
UniProt:O15355 PPM1G			0.725	6
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.714	4
UniProt:Q15554 TERF2	2	p-S365-TERF2 [nucleoplasm] (R-HSA-9686530) TERF2 [nucleoplasm] (R-HSA-174895)	0.681	4
UniProt:P58876 H2BC5	9	Ub-HIST1H2BD [nucleoplasm] (R-HSA-6782546) AcK-HIST1H2BD [nucleoplasm] (R-HSA-4549255) HIST1H2BD [extracellular region] (R-HSA-977561) AcK16-HIST1H2BD [nucleoplasm] (R-HSA-4568633) AcK6-HIST1H2BD [nucleoplasm] (R-HSA-4568642) AcK21-HIST1H2BD [nucleoplasm] (R-HSA-4568627) AcK13-HIST1H2BD [nucleoplasm] (R-HSA-4568645) Ub-121-HIST1H2BD [nucleoplasm] (R-HSA-3364025) HIST1H2BD [nucleoplasm] (R-HSA-181912)	0.669	3
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.667	6
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.643	5
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.643	3
UniProt:Q8N108 MIER1			0.643	5
UniProt:P46783 RPS10	2	RPS10 [cytosol] (R-HSA-72325) RPS10 [nucleoplasm] (R-HSA-6798733)	0.643	4
UniProt:O94880 PHF14			0.643	4
UniProt:P55209 NP1L1			0.643	5
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.643	5
UniProt:Q16695 H3-4	3	Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) HIST3H3 [nucleoplasm] (R-HSA-181914)	0.641	12
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.604	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.577	6
UniProt:Q6ZW49-1 PAXIP1			0.558	7
UniProt:Q99986 VRK1	2	VRK1 [cytosol] (R-HSA-2995381) VRK1 [nucleoplasm] (R-HSA-2528998)	0.544	3
UniProt:Q6P4T3 Q6P4T3			0.544	2
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.544	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.537	9
UniProt:Q8IUE6 H2AC21	11	K63polyUb-HIST2H2AB [nucleoplasm] (R-HSA-6783295) Ub-HIST2H2AB [nucleoplasm] (R-HSA-6782490) AcK6-HIST2H2AB [nucleoplasm] (R-HSA-4568609) Me2aR30-HIST2H2AB [nucleoplasm] (R-HSA-5244567) MeR30-HIST2H2AB [nucleoplasm] (R-HSA-5244540) Me2aR4-HIST2H2AB [nucleoplasm] (R-HSA-5244588) MeR4-HIST2H2AB [nucleoplasm] (R-HSA-5244632) Me2aR12-HIST2H2AB [nucleoplasm] (R-HSA-5229314) MeR12-HIST2H2AB [nucleoplasm] (R-HSA-5229207) HIST2H2AB [nucleoplasm] (R-HSA-4549212) AcK-HIST2H2AB [nucleoplasm] (R-HSA-4551335)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.527	2
UniProt:P62269 RPS18	2	RPS18 [cytosol] (R-HSA-72341) RPS18 [nucleoplasm] (R-HSA-6798701)	0.527	2
UniProt:Q01831 XPC	5	monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441)	0.527	3
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.527	2
UniProt:Q9H2C0 GAN	1	GAN [cytosol] (R-HSA-976014)	0.527	3
UniProt:Q3T8J9 GON4L			0.527	4
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	4
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	2
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300)	0.527	2
UniProt:Q5TEC6 H37			0.527	3
UniProt:Q2M2E5 CE064			0.527	2
UniProt:Q96RY5 CRML			0.527	3
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	3
UniProt:Q15527 SURF2			0.527	2
UniProt:Q9UHA2 S18L2			0.527	4
UniProt:Q96LZ2 MAGBA			0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933)	0.527	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.527	4
UniProt:P62857 RPS28	2	RPS28 [cytosol] (R-HSA-72365) RPS28 [nucleoplasm] (R-HSA-6791202)	0.527	2
UniProt:Q96HA7 TONSL			0.527	4
UniProt:P23527 H2BC17	9	Ub-HIST1H2BO [nucleoplasm] (R-HSA-6782549) AcK-HIST1H2BO [nucleoplasm] (R-HSA-4549268) HIST1H2BO [extracellular region] (R-HSA-977557) AcK13-HIST1H2BO [nucleoplasm] (R-HSA-4568712) AcK21-HIST1H2BO [nucleoplasm] (R-HSA-4568713) AcK16-HIST1H2BO [nucleoplasm] (R-HSA-4568681) AcK6-HIST1H2BO [nucleoplasm] (R-HSA-4568708) Ub-121-HIST1H2BO [nucleoplasm] (R-HSA-3364033) HIST1H2BO [nucleoplasm] (R-HSA-181910)	0.527	3
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	2
UniProt:P62841 RPS15	2	RPS15 [cytosol] (R-HSA-72335) RPS15 [nucleoplasm] (R-HSA-6798706)	0.527	3
UniProt:Q9Y4C8 RBM19			0.527	3
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	3
UniProt:Q14207 NPAT			0.527	2
UniProt:Q6PH81 CP087			0.527	3
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.527	2
UniProt:P11487 FGF3	1	FGF3 [extracellular region] (R-HSA-189886)	0.527	2
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.527	2
UniProt:P22492 H1T			0.527	4
UniProt:Q96P70 IPO9			0.527	4
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	3
UniProt:Q6ZRQ5 MMS22			0.527	4
UniProt:Q8TAQ5 ZNF420	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.527	2
UniProt:P0CB38 PAB4L			0.527	2
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.527	3
UniProt:Q9Y2T7 YBOX2			0.527	2
UniProt:O43167 ZBT24			0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	4
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.527	3
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.527	2
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	3
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.527	3
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	3
UniProt:Q9H6F5 CCD86			0.527	3
UniProt:P61769-PRO_0000018779 B2M			0.524	5
UniProt:P46933-1 APBB1			0.524	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.524	3
UniProt:P18887 XRCC1	1	XRCC1 [nucleoplasm] (R-HSA-67455)	0.491	3
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.491	2
UniProt:Q9NX02 NALP2			0.463	3
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2

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