Reactome | PRKN polyubiquitinates RIPK3

PRKN polyubiquitinates RIPK3

Stable Identifier

R-HSA-9793485

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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E3 ubiquitin-protein ligase parkin (PRKN, also known as PARK2), was shown to negatively regulate necroptosis in human and mouse cells through promoting K33-linked polyubiquitination of receptor-interacting protein 3 (RIPK3) (Lee SB et al. 2019). PRKN-catalyzed polyubiquitination of RIPK3 at K197, K302 or K364 decreased RIPK1:RIPK3-mediated necroptosis in human colorectal adenocarcinoma HT-29 cells in response to T/C/Z treatment (TNF-ɑ with cycloheximide and the caspase inhibitor zVAD (Z)) (Lee SB et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
31358971	The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome Tong, SY, Chung, JO, Lou, Z, Kim, SS, Zhang, JS, Luo, Q, Han, SA, Lee, SB, Choi, SI, Nowsheen, S, Kim, JJ, Fan, Y, Springer, W, Park, SY, Fiesel, FC, Yin, P, Guo, LS, Aziz, A, Aziz, K	Nat Cell Biol	2019