TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]

Stable Identifier
R-HSA-9793688
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
GO Cellular Component
death-inducing signaling complex (0031264)
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
20005846 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Koschny, R, Feltham, R, Rieser, E, Haas, TL, Silke, J, Walczak, H, Warnken, U, Gerlach, B, Cordier, SM, Vince, J, Wenger, T, Schmukle, AC, Emmerich, CH, Komander, D

Mol. Cell 2009
Participants
components
Participates
as an output of
as a member of
This entity regulates
Positively
Inferred To
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Bos taurus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Sus scrofa)
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