ABCG2 transports Cipro from hepatic cell to extracellular space

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Concentration of ciprofloxacin (Cipro) in bile is greater than in hepatic cells. ABCG2 is localized in the apical membrane of hepatic cells (Matsushima et al, 2005). ABCG2 transports Cipro to extracellular space which, in this reaction, is the bile duct lumen (Ando et al, 2007; reviewed by Alvarez et al, 2008).
Literature References
PubMed ID Title Journal Year
17639028 Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones

Sugiyama, Y, Schinkel, AH, Alvarez, AI, Ando, T, Kusuhara, H, Merino, G

Drug Metab Dispos 2007
15901800 Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein

Sugiyama, Y, Sasaki, M, Matsushima, S, Hirano, M, Maeda, K, Suzuki, H, Kondo, C

J Pharmacol Exp Ther 2005
18200507 Fluoroquinolone efflux mediated by ABC transporters

Molina, AJ, Alvarez, AI, Prieto, JG, Merino, G, Real, R, PĂ©rez, M

J Pharm Sci 2008
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCG2 tetramer [apical plasma membrane ]

Orthologous Events
Cite Us!