AcK-NFE2L2 binds the BCL2 gene

Stable Identifier
R-HSA-9796059
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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AcK-NFE2L2 binds the BCL2 gene
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NFE2L2 upregulates BCL2 expression and apoptotic cell death with implications in antioxidant protection, survival of cancer cells, and drug resistance. Mutagenesis and transfection assays identified an antioxidant response element between nucleotides -3148 and -3140 on the reverse strand of the Bcl-2 gene promoter that was essential for the activation of Bcl-2 gene expression (Niture et al 2012)
Literature References
PubMed ID Title Journal Year
22275372 Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis

Niture, SK, Jaiswal, AK

J Biol Chem 2012
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Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-08-04)
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