Reactome | PTPRF [endosome membrane]

PTPRF [endosome membrane]

Stable Identifier

R-HSA-9815889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

LAR, LAR protein precursor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10586 PTPRF

Gene Names

PTPRF, LAR

Chain

signal peptide:1-29, chain:30-1907

Reference Genes

BioGPS Gene:5792 PTPRF

COSMIC (genes):PTPRF PTPRF

CTD Gene:5792 PTPRF

dbSNP Gene:5792 PTPRF

ENSEMBL:ENSG00000142949 PTPRF

HGNC:9670 PTPRF

KEGG:hsa:5792 PTPRF

Monarch:5792 PTPRF

NCBI Gene:5792 PTPRF

OMIM:179590 PTPRF

UCSC:P10586 PTPRF

Reference Transcript

Other Identifiers

11715844_s_at

11715845_s_at

11751823_a_at

11754235_a_at

11754236_a_at

16663621

200635_PM_s_at

200635_s_at

200636_PM_s_at

200636_s_at

200637_PM_s_at

200637_s_at

2333323

2333326

2333327

2333328

2333329

2333333

2333338

2333339

2333340

2333343

2333344

2333345

2333354

2333355

2333356

2333357

2333358

2333359

2333360

2333361

2333362

2333363

2333364

2333370

2333372

2333373

2333374

2333375

2333377

2333378

2333379

2333381

2333382

2333383

2333385

2333386

2333387

2333388

2333389

2333390

2333395

2333399

2333400

2333401

2333404

2333405

2333408

2333409

2333410

2333411

2333412

2333413

2333414

2333415

2333417

2333419

2333420

2333421

2333422

2333423

2333424

36204_at

5792

7900792

A_14_P128889

A_23_P200984

A_24_P385313

A_33_P3276282

GE60236

GE84583

GE84939

GO:0003824

GO:0004721

GO:0004725

GO:0005001

GO:0005515

GO:0005737

GO:0005886

GO:0006470

GO:0007155

GO:0007185

GO:0008201

GO:0010975

GO:0016020

GO:0016311

GO:0016477

GO:0016787

GO:0031102

GO:0035335

GO:0035373

GO:0043005

GO:0043025

GO:0043226

GO:0044877

GO:0048679

GO:0048856

GO:0048870

GO:0050839

GO:0060089

GO:0070062

GO:0099560

GO:0140096

GO:1900121

HMNXSV003046414

HMNXSV003052730

Hs.75216.0.S1_3p_a_at

Hs.75216.0.S2_3p_a_at

ILMN_1798081

ILMN_2380163

PH_hs_0004288

TC01000548.hg

Y00815_at

g4506310_3p_a_at

Participates

as a candidate of

PTPN1, PTPRF [endosome membrane] (Homo sapiens)

Other forms of this molecule

PTPRF [plasma membrane]

Inferred To

Homologues of PTPRF [endosome membrane] (Drosophila melanogaster)

PTPRF [endosome membrane] (Bos taurus)

PTPRF [endosome membrane] (Canis familiaris)

PTPRF [endosome membrane] (Drosophila melanogaster)

PTPRF [endosome membrane] (Gallus gallus)

PTPRF [endosome membrane] (Mus musculus)

PTPRF [endosome membrane] (Rattus norvegicus)

PTPRF [endosome membrane] (Sus scrofa)

Ptp52F [endosome membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_002831.2, NP_569707.2

Guide to Pharmacology - Targets

1855

OpenTargets

ENSG00000142949

ENSEMBL

ENST00000438120, ENSP00000353030, ENSP00000398822, ENST00000359947

ZINC - Substances

PTPRF_HUMAN

ZINC - Biogenic

PTPRF_HUMAN

ZINC target

P10586

PRO

P10586

GlyGen

P10586

PDB

6KR4, 4N5U, 2YD8, 2DN7, 2DJU, 1LAR, 6TPU, 6TPT, 2EDX, 6TPV, 6TPW, 2EDY, 2YD5

ZINC - Metabolites

PTPRF_HUMAN

HPA

ENSG00000142949-PTPRF

Pharos - Targets

P10586

ZINC - Predictions - Purchasable

PTPRF_HUMAN

Orphanet

PTPRF

HMDB Protein

HMDBP08943

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.547	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.499	2