Reactome | C3 convertases spontaneously dissociate

C3 convertases spontaneously dissociate

Stable Identifier

R-HSA-981621

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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C3b:Bb is naturally labile with a half-life of ~90 s. unless bound to properdin on the cell surface (Medicus et al. 1976). C4bC2a is also unstable, lasting at best a few minutes (Kerr et al. 1980). Decay is associated with the release of the Bb or C2a fragments respectively into the fluid phase. The liberated C3b/C4b is able to re-bind Bb/C2a if Factor B/C2 are present.

Literature References

PubMed ID	Title	Journal	Year
978134	Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway Medicus, RG, Muller-Eberhard, HJ, Gotze, O	J Exp Med	1976
6906228	The human complement system: assembly of the classical pathway C3 convertase Kerr, MA	Biochem J	1980