NFE2L2 regulating anti-oxidant/detoxification enzymes

Stable Identifier
R-HSA-9818027
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2 regulating anti-oxidant/detoxification enzymes
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Subpathway representing cytoprotective genes regulated by NFE2L2 (NRF2). NFE2L2 is well-studied for its role in oxidative stress where it gets activated by ROS and then induces a plethora of gene expression regulation the oxidative damage. It induces genes/enzymes that regulate the phase 2 detoxification system (eg. GSTs and Glutathione system), ROS scavenging (SODs,PRDX1 ) and cytoprotection (HO1) by regulating inflammation and tissue damage (Tonelli et al, 2018; Shaw et al, 2020)
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Orthologous Events
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Authored
Tiwari, K  (2022-10-10)
Created
Tiwari, K  (2022-10-10)
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