Reactome | KMT2B [cytosol]

KMT2B [cytosol]

Stable Identifier

R-HSA-9818624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Histone-lysine N-methyltransferase MLL2, MLL2_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UMN6 KMT2B

Gene Names

KMT2B, HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7

Chain

initiator methionine:, chain:2-2715

Reference Genes

BioGPS Gene:9757 KMT2B

COSMIC (genes):KMT2B KMT2B

CTD Gene:9757 KMT2B

dbSNP Gene:9757 KMT2B

ENSEMBL:ENSG00000272333 KMT2B

HGNC:15840 KMT2B

KEGG:hsa:9757 KMT2B

Monarch:9757 KMT2B

NCBI Gene:9757 KMT2B

OMIM:606834 KMT2B

UCSC:Q9UMN6 KMT2B

Reference Transcript

RefSeq:NM_014727.2 KMT2B

Other Identifiers

11718170_a_at

11746661_a_at

11760531_at

16861152

203419_3p_at

203419_PM_at

203419_at

217075_PM_x_at

217075_x_at

38284_at

3830713

3830717

3830718

3830719

3830720

3830721

3830722

3830723

3830724

3830725

3830726

3830727

3830728

3830729

3830730

3830731

3830732

3830733

3830734

3830735

3830736

3830737

3830738

3830739

3830740

3830741

3830742

3830743

3830744

3830746

3830747

3830748

3830749

3830750

3830751

3830752

3830753

3830754

3830755

3830756

3830757

3830758

3830759

3830760

3830761

3830762

3830763

3830764

3830765

3830766

3830767

3830768

3830769

3830770

3830771

3830772

3830773

3830774

3830775

3830776

3830777

3830778

3830779

3830780

3830781

3830782

3830783

3830785

3830786

3830787

3830788

76850_at

8027956

89018_at

9757

A_14_P124415

A_14_P133476

A_14_P139314

A_23_P142421

A_33_P3221761

GE55176

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006355

GO:0008168

GO:0008170

GO:0008270

GO:0008276

GO:0008757

GO:0016279

GO:0016740

GO:0032259

GO:0035097

GO:0042800

GO:0043226

GO:0044665

GO:0045322

GO:0045893

GO:0046872

GO:0140096

GO:0140938

GO:0140945

GO:0140999

HMNXSV003032710

Hs.92236.1.S1_3p_a_at

ILMN_1715968

PH_hs_0027732

TC19000483.hg

g7662045_3p_at

g7662045_3p_x_at

Participates

as an input of

TASP1 cleaves KMT2B (Homo sapiens)

Other forms of this molecule

KMT2B(2-2062) [cytosol]

KMT2B(2063-2715) [cytosol]

KMT2B(2063-2715) [nucleoplasm]

KMT2B(2-2062) [nucleoplasm]

Cross References

Guide to Pharmacology - Targets

2689

ENSEMBL

ENST00000420124, ENSP00000398837

OpenTargets

ENSG00000272333

HPA

ENSG00000272333-KMT2B

ZINC - Substances

KMT2B_HUMAN

ZINC target

Q9UMN6

PRO

Q9UMN6

Pharos - Targets

Q9UMN6

GlyGen

Q9UMN6

HMDB Protein

HMDBP09020

PDB

4PZI, 7BRE, 4ERZ, 3UVM

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.926	9
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.757	5
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.69	4
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.527	2
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.524	2
UniProt:Q9UBL3-3 ASH2L			0.499	2
UniProt:O00255 MEN1	4	MEN1 [cytosol] (R-HSA-5672315) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) MEN1 [nucleoplasm] (R-HSA-2186626)	0.462	2
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.462	4

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