Reactome | HCFC2 [nucleoplasm]

HCFC2 [nucleoplasm]

Stable Identifier

R-HSA-9821232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Host cell factor 2, HCFC2_HUMAN, HCF2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
      - HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)
        
        HCFC1,HCFC2 [nucleoplasm] (Homo sapiens)
        
        HCFC2 [nucleoplasm] (Homo sapiens)
        
        MLL1 complex,MLL1 complex:MEN1:HCFC1,HCFC2 [nucleoplasm] (Homo sapiens)
        
        MLL1 complex:HCFC2 [nucleoplasm] (Homo sapiens)
        
        HCFC2 [nucleoplasm] (Homo sapiens)
        
        MLL1 complex:MEN1:HCFC2 [nucleoplasm] (Homo sapiens)
        
        HCFC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5Z7 HCFC2

Gene Names

HCFC2

Chain

chain:1-792

Reference Genes

BioGPS Gene:29915 HCFC2

COSMIC (genes):HCFC2 HCFC2

CTD Gene:29915 HCFC2

dbSNP Gene:29915 HCFC2

ENSEMBL:ENSG00000111727 HCFC2

HGNC:24972 HCFC2

KEGG:hsa:29915 HCFC2

Monarch:29915 HCFC2

NCBI Gene:29915 HCFC2

OMIM:607926 HCFC2

UCSC:Q9Y5Z7 HCFC2

Reference Transcript

RefSeq:NM_013320.2 HCFC2

Other Identifiers

11724545_at

11724546_at

16756136

219484_PM_at

219484_at

235264_PM_at

235264_at

29915

3429407

3429408

3429409

3429410

3429411

3429414

3429415

3429416

3429417

3429418

3429420

3429421

3429422

3429424

3429425

3429426

3429427

3429428

3429429

3429430

3429431

3429432

3429433

3429434

3429435

3429436

3429437

3429439

46110_at

51507_at

58124_at

58762_r_at

7958158

A_14_P127030

A_14_P135104

A_23_P25403

A_32_P85539

A_33_P3250018

GE58517

GO:0000122

GO:0002376

GO:0003712

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0016032

GO:0016604

GO:0034139

GO:0035097

GO:0043226

GO:0044665

GO:0045893

GO:0048188

GO:0060090

GO:0071339

GO:0098542

GO:0140110

GO:0140374

GO:1902615

HMNXSV003006343

Hs.110376.0.A1_3p_at

ILMN_1674297

PH_hs_0003642

TC12000807.hg

g7019404_3p_at

Participates

as a component of

as a member of

HCFC1,HCFC2 [nucleoplasm] (Homo sapiens)

Inferred To

Hcfc2 [nucleoplasm] (Mus musculus)

Hcfc2 [nucleoplasm] (Rattus norvegicus)

HCFC2 [nucleoplasm] (Bos taurus)

HCFC2 [nucleoplasm] (Canis familiaris)

HCFC2 [nucleoplasm] (Gallus gallus)

HCFC2 [nucleoplasm] (Sus scrofa)

hcf-1 [nucleoplasm] (Caenorhabditis elegans)

Hcf [nucleoplasm] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000442942, ENST00000544223, ENST00000229330, ENSP00000229330, ENSG00000111727

OpenTargets

ENSG00000111727

GeneCards

HCFC2

HPA

ENSG00000111727-HCFC2

PRO

Q9Y5Z7

Pharos - Targets

Q9Y5Z7

GlyGen

Q9Y5Z7

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.725	4
UniProt:P14316 IRF2	2	IRF2 [cytosol] (R-HSA-1015681) IRF2 [nucleoplasm] (R-HSA-994031)	0.643	3
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.623	5
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.564	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.527	4
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.527	4
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	3
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	3
UniProt:Q8NFC6 BOD1L1	1	BOD1L1 [nucleoplasm] (R-HSA-8954547)	0.527	4
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.527	3
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.527	3

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