Reactome | AKAP8L [nucleoplasm]

AKAP8L [nucleoplasm]

Stable Identifier

R-HSA-9821364

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

A-kinase anchor protein 8-like, AKP8L_HUMAN, AKAP95

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9ULX6 AKAP8L

Gene Names

AKAP8L, NAKAP, NAKAP95, HRIHFB2018

Chain

chain:1-646

Reference Genes

BioGPS Gene:26993 AKAP8L

COSMIC (genes):AKAP8L AKAP8L

CTD Gene:26993 AKAP8L

dbSNP Gene:26993 AKAP8L

ENSEMBL:ENSG00000011243 AKAP8L

HGNC:29857 AKAP8L

Monarch:26993 AKAP8L

NCBI Gene:26993 AKAP8L

OMIM:609475 AKAP8L

UCSC:Q9ULX6 AKAP8L

Reference Transcript

Other Identifiers

11730171_a_at

11750884_a_at

16869860

215741_PM_x_at

215741_x_at

218064_3p_s_at

218064_PM_s_at

218064_s_at

222160_PM_at

222160_at

227691_PM_at

227691_at

240554_PM_at

240554_at

26993

37886_at

3853343

3853344

3853346

3853347

3853348

3853349

3853350

3853351

3853352

3853353

3853366

3853367

3853368

3853369

3853370

3853371

3853372

3853373

3853374

3853375

3853376

3853377

3853378

3853379

3853380

3853381

3853382

3853383

3853384

3853385

3853386

3853387

3853388

3853389

3853390

3853391

3853392

3853393

3853394

3853395

3853396

3853397

3853398

3853399

3853400

3853401

3853403

3853405

43345_at

55687_at

55726_at

67727_at

8035023

90105_at

A_23_P153767

A_24_P934594

GE55840

GO:0000785

GO:0003677

GO:0003723

GO:0003824

GO:0005515

GO:0005521

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006397

GO:0007076

GO:0008380

GO:0010793

GO:0016071

GO:0016301

GO:0016363

GO:0016605

GO:0016607

GO:0016740

GO:0017151

GO:0034237

GO:0042826

GO:0043226

GO:0043227

GO:0043229

GO:0044839

GO:0045944

GO:0046872

GO:0051081

GO:0061024

GO:1990904

HMNXSV003008773

HMNXSV003027342

Hs.105549.0.S1_3p_at

Hs.187670.0.A1_3p_at

Hs.96200.1.S1_3p_a_at

Hs.96200.1.S1_3p_x_at

Hs.96200.2.S1_3p_at

ILMN_1768962

PH_hs_0031425

TC19001254.hg

g7657354_3p_a_at

Participates

as a component of

as an input of

Inferred To

akap8l [nucleoplasm] (Xenopus tropicalis)

AKAP8L [nucleoplasm] (Bos taurus)

AKAP8L [nucleoplasm] (Gallus gallus)

AKAP8L [nucleoplasm] (Sus scrofa)

Akap8l [nucleoplasm] (Mus musculus)

Akap8l [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000011243

ENSEMBL

ENSP00000470952, ENST00000397410, ENSP00000380557, ENST00000595465

HPA

ENSG00000011243-AKAP8L

PRO

Q9ULX6

Pharos - Targets

Q9ULX6

GlyGen

Q9ULX6

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.666	4
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.612	5
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:Q9BTL3 RAMAC			0.556	3
UniProt:Q8N895 ZN366			0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:Q96M29 TEKT5			0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.556	3
UniProt:Q12950 FOXD4			0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q14657 LAGE3	1	LAGE3 [nucleoplasm] (R-HSA-6784525)	0.556	3
UniProt:Q01085-2 TIAL1			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:Q9Y5R4 HEMK1			0.556	3
UniProt:Q9ULV5-2 HSF4			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q8TAP9 MPLKI			0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:P15202	5	CAT [cytosol] (R-SCE-9033141) CAT [peroxisomal matrix] (R-SCE-51417) CAT [ficolin-1-rich granule lumen] (R-SCE-6801279) CAT [extracellular region] (R-SCE-6806458) CAT [secretory granule lumen] (R-SCE-6801311)	0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q14129 DGCR6			0.556	3
UniProt:P62328 TMSB4X	2	TMSB4X [extracellular region] (R-HSA-349753) TMSB4X [platelet alpha granule lumen] (R-HSA-349758)	0.556	3
UniProt:Q9UPU9-3 SAMD4A			0.556	3
UniProt:Q8N4L8 CCD24			0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:Q86VE0 MYPOP			0.556	3
UniProt:Q9Y5E9 PCDBE			0.556	3
UniProt:Q8WU58 F222B			0.556	3
UniProt:P33240 CSTF2	1	CSTF2 [nucleoplasm] (R-HSA-72003)	0.556	3
UniProt:Q8TEC5 SH3R2			0.556	3
UniProt:Q8N5M1 ATPF2			0.556	3
UniProt:Q9Y2V2 CHSP1			0.556	3
UniProt:A8K8V0 ZNF785	1	ZNF785 [nucleoplasm] (R-HSA-3323098)	0.556	3
UniProt:Q494U1-3 PLEKHN1			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9NP98 MYOZ1			0.556	3
UniProt:Q64LD2-2 WDR25			0.556	3
UniProt:Q8AZK7 EBNA5			0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	9
UniProt:Q68DV7 RNF43	10	RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs41 [plasma membrane] (R-HSA-9666643) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 R132 [plasma membrane] (R-HSA-9666650) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 E174* [plasma membrane] (R-HSA-5340574)	0.508	2
UniProt:Q9R1C7	1	Prpf40a [nucleoplasm] (R-MMU-8867890)	0.508	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.499	2
UniProt:P12504 VIF			0.462	2

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