Reactome | CXXC1 and WDR82 bind SET1A complex

CXXC1 and WDR82 bind SET1A complex

Stable Identifier

R-HSA-9821475

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SET1A complex associates with CXXC1 (also known as CFP1) and WDR82 proteins, which interact with the C-terminus and the N-terminus of SETD1A, respectively (Lee et al. 2007; Lee and Skalnik 2008; Wu et al. 2008; van Nuland et al. 2013). The association of CXXC1 and the WRAD complex with the C-terminus of SETD1A increases the protein stability of SETD1A (Lee et al. 2007; Wu et al. 2008). WDR82 binds to RNA polymerase II phosphorylated on serine S5 of heptad repeats during transcription initiation and may act to recruit the SET1A complex to promoters of transcriptionally active genes (Lee and Skalnik 2008). The association of WDR82 with chromatin likely requires prior ubiquitination of histone H2B (Wu et al. 2008). WDR82 may facilitate association of CXXC1 with SETD1A but does not affect the association of SETD1A with the WRAD complex (Lee and Skalnik 2008). Based on quantitative analysis in HeLa cells, CXXC1 may bind the SET1A complex as a dimer (van Nuland et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M	Mol Cell Biol	2013
18838538	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS Florens, L, Martin-Brown, S, Lee, JS, Washburn, M, Wu, M, Shilatifard, A, Wang, PF	Mol Cell Biol	2008
17998332	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes Skalnik, DG, Lee, JH	Mol Cell Biol	2008
17355966	Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex Skalnik, DG, Tate, CM, You, JS, Lee, JH	J Biol Chem	2007