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PSIP1 binds MEN1 associated with MLL2 complex
Stable Identifier
R-HSA-9821902
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
PSIP1 binds MEN1 associated with MLL2 complex (Homo sapiens)
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PSIP1 (also known as LEDGF) is co-immunoprecipitated with MEN1-bound MLL2 complexes (van Nuland et al. 2013). Although the LEDGF binding motif (LBM) that is present in KMT2A is missing in KMT2B (Huang et al. 2012), PSIP1 can directly interact with MEN1 (Huang et al. 2012). Based on quantitative studies in HeLa cells, all PSIP1-containing MLL1/MLL2 complexes contain MEN1, but only about 25% of MEN1-containing MLL1/MLL2 complexes contain PSIP1 (van Nuland et al. 2013). PSIP1 appears to be more prevalent in MLL2:MEN1 complexes than in MLL1:MEN1 complexes (van Nuland et al. 2013). HCFC2 has been found to be co-immunoprecipitated with PSIP1, so it is possible that a portion of MLL2 complexes with MEN1 and PSIP1 also include HCFC1 or HCFC2 (van Nuland et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
23508102
Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
Pallaki, P
,
Smits, AH
,
van Nuland, R
,
Jansen, PW
,
Timmers, HT
,
Vermeulen, M
Mol Cell Biol
2013
Participants
Input
MLL2 complex:MEN1 [nucleoplasm]
(Homo sapiens)
PSIP1 [nucleoplasm]
(Homo sapiens)
Output
MLL2 complex:MEN1:PSIP1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
Orthologous Events
PSIP1 binds MEN1 associated with MLL2 complex (Bos taurus)
PSIP1 binds MEN1 associated with MLL2 complex (Drosophila melanogaster)
PSIP1 binds MEN1 associated with MLL2 complex (Mus musculus)
PSIP1 binds MEN1 associated with MLL2 complex (Rattus norvegicus)
PSIP1 binds MEN1 associated with MLL2 complex (Sus scrofa)
Authored
Orlic-Milacic, M (2023-01-06)
Reviewed
Ge, K (2023-02-08)
Van, H (2023-02-08)
Created
Orlic-Milacic, M (2022-12-14)
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