Reactome | NPM2 [nucleoplasm]

NPM2 [nucleoplasm]

Stable Identifier

R-HSA-9821980

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleoplasmin-2, NPM2_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86SE8 NPM2

Gene Names

NPM2

Chain

chain:1-214

Reference Genes

BioGPS Gene:10361 NPM2

COSMIC (genes):NPM2 NPM2

CTD Gene:10361 NPM2

dbSNP Gene:10361 NPM2

ENSEMBL:ENSG00000158806 NPM2

ENSEMBL_homo_sapiens_GENE:ENSG00000158806.14 NPM2

HGNC:7930 NPM2

KEGG Gene (Homo sapiens):10361 NPM2

Monarch:10361 NPM2

NCBI Gene:10361 NPM2

OMIM:608073 NPM2

UCSC:Q86SE8 NPM2

Reference Transcript

Other Identifiers

10361

11728149_a_at

11748906_a_at

17066420

230977_PM_at

230977_at

3089056

3089057

3089058

3089059

3089060

3089061

3089062

3089063

3089064

3089066

3089068

3089069

3089070

3089072

3089074

3089075

3089076

77895_at

8144982

A_23_P169007

A_33_P3261869

A_33_P3272479

GE790983

GO:0000278

GO:0000785

GO:0001824

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0006260

GO:0006325

GO:0006338

GO:0007096

GO:0007338

GO:0009994

GO:0019899

GO:0022414

GO:0030154

GO:0042393

GO:0042802

GO:0043226

GO:0045740

GO:0045836

GO:0048856

GO:0051054

GO:0140013

GO:0140014

HMNXSV003014991

HMNXSV003021772

Hs.131055.0.A1_3p_at

ILMN_1775736

PH_hs_0007748

PH_hs_0037382

TC08000161.hg

Participates

as an output of

HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)

as a component of

as an input of

NPM2 and HIRA bind p-S9-PRM1:dsDNA (Homo sapiens)

Cross References

RefSeq

XP_011542665.1, NP_877724.1, XP_016868438.1, NP_001273609.1, XP_011542664.1, XP_016868437.1, NP_001273610.1

OpenTargets

ENSG00000158806

GeneCards

Q86SE8

HPA

ENSG00000158806-NPM2

Ensembl

ENSP00000370941, ENST00000381530, ENST00000621538, ENSP00000289820, ENST00000521157, ENST00000518119, ENSP00000381032, ENST00000289820, ENSP00000481077, ENST00000615914, ENSP00000481018, ENSP00000427741, ENST00000397940, ENSG00000158806, ENSP00000429413

PRO

Q86SE8

Pharos - Targets

Q86SE8

PDB

3T30

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75607 NPM3			0.801	6
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.743	8
UniProt:Q9H190 SDCB2			0.666	4
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	2
UniProt:Q9H4K7 MTG2			0.527	2

Cite Us!