HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA

Stable Identifier
R-HSA-9822185
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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HIRA, NPM2, and possibly NPM1 and NPM3 assemble individual histones into nucleosomes for chromatin in the male pronucleus of the zygote (inferred from mouse nuclei). Chromatin in both pronuclei of the zygote contains histone H3.3, histone H2AX (H2A.X), and histone H1-8 (H1FOO). Histone H3.3 is chaperoned to the nucleosome by HIRA and is found in active chromatin. Oocyte-specific histone H1-8 begins assembling onto zygotic chromatin within 5 minutes of fertilization (inferred from mouse zygotes). Nucleoplasmin (NP) from Xenopus, a homolog of human NPM proteins, is able to bind histones and assemble nucleosomes in vitro (Franco et al. 2019).

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Catalyst Activity

histone chaperone activity of HIRA:NPM2:dsDNA [nucleoplasm]

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