Reactome | PDE4B-3 [cytosol]

PDE4B-3 [cytosol]

Stable Identifier

R-HSA-9822899

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        PKA phosphorylates PDE4B (Homo sapiens)
        
        PDE4B-3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07343-3 PDE4B

Gene Names

PDE4B, DPDE4

Other Identifiers

11724095_a_at

11724096_a_at

11726005_a_at

11734712_a_at

203708_PM_at

203708_at

211302_PM_s_at

211302_s_at

2340532

2340533

2340542

2340543

2340544

2340546

2340549

2340550

2340582

2340587

2340588

2340590

2340615

2340616

2340617

2340618

2340619

2340630

2340631

2340635

2340636

2340637

2340639

2340640

2340641

2340643

2340648

2340649

2340650

2340672

33705_at

5142

7902104

A_14_P129209

A_14_P136724

A_23_P74278

A_24_P325333

A_24_P921129

GE57671

GO:0000930

GO:0001780

GO:0002376

GO:0003012

GO:0003013

GO:0003824

GO:0004114

GO:0004115

GO:0005246

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005891

GO:0006198

GO:0007165

GO:0008021

GO:0008081

GO:0008092

GO:0014069

GO:0016020

GO:0016787

GO:0023052

GO:0030018

GO:0030552

GO:0030593

GO:0031410

GO:0032729

GO:0032743

GO:0043015

GO:0043197

GO:0043226

GO:0044325

GO:0046872

GO:0048471

GO:0048870

GO:0050852

GO:0050900

GO:0055085

GO:0055086

GO:0060076

GO:0071222

GO:0071466

GO:0071872

GO:0071878

GO:0071944

GO:0086004

GO:0098772

GO:1901135

GO:1901898

GO:1902514

HMNXSV003054497

ILMN_1782922

ILMN_2288976

ILMN_2296439

ILMN_2340259

L20971_at

PH_hs_0000027

TC01000733.hg

g347121_3p_a_at

g4505662_3p_at

Participates

as an input of

PKA phosphorylates PDE4B (Homo sapiens)

Other forms of this molecule

p-S54-PDE4B-3 [cytosol]

Inferred To

PDE4B [cytosol] (Canis familiaris)

Homologues of PDE4B-3 [cytosol] (Dictyostelium discoideum)

Homologues of PDE4B-3 [cytosol] (Plasmodium falciparum)

PDE4B-3 [cytosol] (Bos taurus)

PDE4B-3 [cytosol] (Caenorhabditis elegans)

PDE4B-3 [cytosol] (Dictyostelium discoideum)

PDE4B-3 [cytosol] (Drosophila melanogaster)

PDE4B-3 [cytosol] (Gallus gallus)

PDE4B-3 [cytosol] (Mus musculus)

PDE4B-3 [cytosol] (Plasmodium falciparum)

PDE4B-3 [cytosol] (Rattus norvegicus)

PDE4B-3 [cytosol] (Sus scrofa)

PDE4B-3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001032417.1, NP_001284370.1, NP_001284369.1, NP_001032416.1, NP_002591.2, NP_001032418.1, NP_001284371.1

ZINC - World Drugs

PDE4B_HUMAN

Guide to Pharmacology - Targets

1301

OpenTargets

ENSG00000184588

ZINC - FDA approved

PDE4B_HUMAN

ZINC - Substances

PDE4B_HUMAN

ZINC - Biogenic

PDE4B_HUMAN

ZINC target

Q07343

PRO

Q07343

PDB

3KKT, 3D3P, 1XOS, 3HMV, 1Y2H, 2QYL, 3W5E, 5K6J, 4KP6, 3O0J, 3HC8, 1Y2J, 1XLX, 6BOJ, 2CHM, 1F0J, 3GWT, 1XOT, 1ROR, 3FRG, 5OHJ, 3WD9, 4WZI, 3G45, 3LY2, 4NW7, 3HDZ, 1XMU, 1XLZ, 1RO6, 3O57, 4MYQ, 1XN0, 8OEG, 1XM6, 1XMY, 4X0F, 5LAQ, 1RO9, 1XM4, 1TB5, 3O56

ZINC - Investigational

PDE4B_HUMAN

ZINC - Metabolites

PDE4B_HUMAN

GeneCards

Q07343

HPA

ENSG00000184588-PDE4B

Ensembl

ENSP00000360084, ENSG00000184588, ENSP00000392947, ENST00000341517, ENSP00000432592, ENST00000371045, ENST00000423207, ENSP00000342637, ENST00000480109, ENST00000329654, ENSP00000332116

Pharos - Targets

Q07343

ZINC - Predictions - Purchasable

PDE4B_HUMAN

HMDB Protein

HMDBP00609