HINT1 binds MITF-M

Stable Identifier
R-HSA-9825751
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HINT1 binds MITF-M
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Deacetylation of HINT1 by SIRT1 promotes the interaction of MITF and HINT1, consequently restricting the transcription factor activity of MITF (Jung et al, 2020).
Literature References
PubMed ID Title Journal Year
32636443 Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells

Jin, GR, Jung, TY, Lee, SY, Ju, BG, Jang, MM, Kim, H, Lee, CY, Lee, SY, Koo, YB, Kim, HS, Kim, CW

Exp Mol Med 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CREBBP [nucleoplasm] (Homo sapiens)
Active Unit
CREBBP [nucleoplasm]
Positively by
Regulator
SIRT1 [nucleoplasm] (Homo sapiens)
Orthologous Events
HINT1 binds MITF-M (Bos taurus)
HINT1 binds MITF-M (Caenorhabditis elegans)
HINT1 binds MITF-M (Canis familiaris)
HINT1 binds MITF-M (Danio rerio)
HINT1 binds MITF-M (Drosophila melanogaster)
HINT1 binds MITF-M (Gallus gallus)
HINT1 binds MITF-M (Mus musculus)
HINT1 binds MITF-M (Rattus norvegicus)
HINT1 binds MITF-M (Sus scrofa)
HINT1 binds MITF-M (Xenopus tropicalis)
Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Created
Rothfels, K  (2023-01-26)
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