Reactome | Growth hormone receptor binds JAK2

Growth hormone receptor binds JAK2

Stable Identifier

R-HSA-982792

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
8343952	Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase Witthuhn, BA, Carter-Su, C, Yang, X, Campbell, GS, Argetsinger, LS, Silvennoinen, O, Ihle, JN	Cell	1993