Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TPP2 [cytosol]
Stable Identifier
R-HSA-983068
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tripeptidyl-peptidase 2, TPP2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)
IFN gamma stimulated aminopeptidases [cytosol] (Homo sapiens)
TPP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29144 TPP2
Gene Names
TPP2
Chain
initiator methionine:, chain:2-1249
Reference Genes
BioGPS Gene:7174 TPP2
COSMIC (genes):TPP2 TPP2
CTD Gene:7174 TPP2
dbSNP Gene:7174 TPP2
ENSEMBL:ENSG00000134900 TPP2
ENSEMBL_homo_sapiens_GENE:ENSG00000134900.13 TPP2
HGNC:12016 TPP2
KEGG Gene (Homo sapiens):7174 TPP2
Monarch:7174 TPP2
NCBI Gene:7174 TPP2
OMIM:190470 TPP2
UCSC:P29144 TPP2
Reference Transcript
RefSeq:NM_001330588.1 TPP2
RefSeq:NM_003291.3 TPP2
Other Identifiers
11754717_a_at
1569857_PM_s_at
1569857_s_at
16776188
203374_PM_s_at
203374_s_at
3499476
3499477
3499478
3499487
3499490
3499491
3499493
3499496
3499499
3499500
3499501
3499502
3499506
3499507
3499508
3499510
3499511
3499512
3499514
3499515
3499516
3499517
3499519
3499520
3499522
3499532
3499538
3499539
3499540
3499544
3499545
3499551
3499552
3499553
3499554
7174
7969881
A_14_P107984
A_14_P112277
A_14_P131981
A_23_P99424
GE58055
GO:0000209
GO:0003824
GO:0004175
GO:0004177
GO:0004252
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006508
GO:0008233
GO:0008236
GO:0008240
GO:0016604
GO:0016787
GO:0036211
GO:0042802
GO:0043226
GO:0080144
GO:0140096
HMNXSV003031299
HMNXSV003046335
Hs.1117.0.S1_3p_a_at
ILMN_1667657
TC13000367.hg
Participates
as a member of
IFN gamma stimulated aminopeptidases [cytosol] (Homo sapiens)
Inferred To
TPP2 [cytosol]
(Bos taurus)
TPP2 [cytosol]
(Canis familiaris)
TPP2 [cytosol]
(Gallus gallus)
TPP2 [cytosol]
(Sus scrofa)
tpp2 [cytosol]
(Schizosaccharomyces pombe)
tpp2 [cytosol]
(Xenopus tropicalis)
TppII [cytosol]
(Drosophila melanogaster)
tpp-2 [cytosol]
(Caenorhabditis elegans)
Tpp2 [cytosol]
(Mus musculus)
Tpp2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001317517.1
,
NP_003282.2
Guide to Pharmacology - Targets
2423
OpenTargets
ENSG00000134900
ZINC - Substances
TPP2_HUMAN
ZINC target
P29144
PRO
P29144
HPA
ENSG00000134900-TPP2
GeneCards
P29144
Ensembl
ENSG00000134900
,
ENST00000376065
,
ENSP00000365233
Pharos - Targets
P29144
ZINC - Predictions - Purchasable
TPP2_HUMAN
Orphanet
23597
HMDB Protein
HMDBP14588
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06746 POLB
2
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
POLB [nucleoplasm]
(R-HSA-53845)
0.781
8
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.666
5
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
ALOX5 [cytosol]
(R-HSA-429010)
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
0.527
2
UniProt:P04798 CYP1A1
1
CYP1A1 [endoplasmic reticulum membrane]
(R-HSA-52623)
0.527
2
UniProt:Q8N4J0 CARNMT1
1
CARNMT1 [cytosol]
(R-HSA-8876689)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text