EYA1, PAX2, and HOX11 paralog bind the SIX2 gene

Stable Identifier
R-HSA-9830917
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EYA1, PAX2, and HOX11 paralog bind the SIX2 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HOXA11 (or HOXC11 or HOXD11), EYA1, and PAX2 physically associate to form a complex which binds upstream of the transcription start site of the SIX2 gene (inferred from mouse homologs). In mice, Hoxa11, Eya1 and Pax2 are individually unable to activate Six2 expression (Gong et al. 2007).
Participants
Input
Output
Participates
as an event of
Inferred From
Eya1, Pax2, and Hox11 paralog bind the Six2 gene (Mus musculus)
Authored
May, B  (2023-03-15)
Created
May, B  (2023-03-17)
Cite Us!