Reactome | HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

Stable Identifier

R-HSA-983100

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lumenal side of endoplasmic reticulum membrane

Synonyms

1A03_HUMAN, HLA-A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04439 HLA-A

Gene Names

HLA-A, HLAA

Chain

signal peptide:1-24, chain:25-365

Reference Genes

BioGPS Gene:3105 HLA-A

COSMIC (genes):HLA-A HLA-A

CTD Gene:3105 HLA-A

dbSNP Gene:3105 HLA-A

ENSEMBL:ENSG00000206503 HLA-A

HGNC:4931 HLA-A

KEGG:hsa:3105 HLA-A

Monarch:3105 HLA-A

NCBI Gene:3105 HLA-A

OMIM:142800 HLA-A

UCSC:P04439 HLA-A

Reference Transcript

Other Identifiers

11749990_x_at

11755303_x_at

11755344_x_at

11762119_x_at

11762150_x_at

11762282_x_at

17006142

17026109

17027344

213932_3p_x_at

213932_PM_x_at

213932_x_at

215313_3p_x_at

215313_PM_x_at

215313_x_at

2900990

2901146

2901160

2901162

2901164

2901180

2901181

2901182

2901183

2901184

2901185

2901186

2901187

2901188

2901189

2901190

2901191

2901192

2901193

2901194

2901195

2901196

2901197

2901198

2901199

2901200

2901201

2901202

2901209

2901216

2901222

2901249

2901289

2901470

2901471

2901631

2948906

2948908

2948910

2948911

2948945

2948946

2948951

3105

41237_at

8117800

8177732

8179041

A_14_P126040

A_23_P408353

A_24_P376483

A_33_P3237574

A_33_P3379962

GE533914

GO:0000139

GO:0001913

GO:0001916

GO:0002250

GO:0002376

GO:0002419

GO:0002474

GO:0002476

GO:0002485

GO:0002486

GO:0002502

GO:0002726

GO:0003723

GO:0005102

GO:0005515

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005797

GO:0005886

GO:0006955

GO:0009897

GO:0009986

GO:0012507

GO:0016020

GO:0016045

GO:0019731

GO:0019882

GO:0019885

GO:0030670

GO:0030881

GO:0031901

GO:0032729

GO:0036037

GO:0042270

GO:0042590

GO:0042605

GO:0042608

GO:0042610

GO:0042612

GO:0042824

GO:0043226

GO:0045087

GO:0046977

GO:0050830

GO:0050852

GO:0055038

GO:0062061

GO:0065003

GO:0070062

GO:0070971

GO:0098542

GO:0098553

GO:2000566

GO:2000568

GO:2001187

HMNXSV003044332

Hs.181244.2.S1_3p_a_at

Hs.181244.2.S1_3p_x_at

Hs.181244.4.S1_3p_a_at

Hs.181244.4.S1_3p_x_at

ILMN_1671054

ILMN_2203950

PH_hs_0039408

TC06000328.hg

TC6_apd_hap1000019.hg

TC6_cox_hap2000026.hg

Participates

as a member of

Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane]

HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane]

HLA-A A-3 [endoplasmic reticulum membrane]

K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]

Inferred To

mhc1zfa [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

mhc1-uba13.5 [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

mhc1-uba15 [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

BFIV21 [lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

mhc1-uea [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

mhc1laa [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

mhc1uba [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

mhc1uma [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

mhc1zea [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

mr1l [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

mhc1-uda [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

mhc1zca [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

LOC100490728 [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

mhc1zba [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

Homologues of HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

Homologues of HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

Homologues of HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (Xenopus tropicalis)

BF1 [lumenal side of endoplasmic reticulum membrane] (Gallus gallus)

mhc1zda [lumenal side of endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_002107.3, NP_001229687.1

OpenTargets

ENSG00000206503

ENSEMBL

ENSP00000366005, ENSP00000516616, ENSP00000379873, ENSP00000516612, ENSP00000516614, ENST00000706901, ENST00000706903, ENST00000376809, ENST00000396634, ENST00000706905

HPA

ENSG00000206503-HLA-A

ZINC - Substances

1A03_HUMAN

ZINC target

P04439

PRO

P04439

Pharos - Targets

P04439

Orphanet

HLA-A

GlyGen

P04439

ZINC - Predictions - Purchasable

1A03_HUMAN

PDB

3BO8, 6AT9, 3VXS, 5EU6, 3NFN, 4N8V, 6MPP, 5HYJ, 7STF, 4WU7, 4F7P, 8D4D, 5EU4, 3O3A, 5E9D, 2HLA, 3MGO, 6AM5, 3QFJ, 4MJ5, 5N1Y, 7UX3, 1QEW, 3GSO, 4JFP, 1BD2, 2PYE, 2GTZ, 5WJN, 5HHQ, 1DUY, 3I6G, 3QFD, 5YXU, 2BNQ, 6O9C, 5DDH, 5NHT, 6RPA, 4JFF, 5C0C, 6D7G, 6JP3, 5HGH, 5MEP, 3MRO, 6APN, 3FT4, 6D78, 8D9S, 1Q94, 5W1W, 3HLA, 2UWE, 2JCC, 5WXC, 3H9H, 2AV7, 3VXR, 6RSY, 5FDW, 3MYJ, 8D4G, 7QPD, 3D39, 1T22, 3FQX, 2P5W, 7PHR, 2X4N, 2VLJ, 1TMC, 3VXU, 3QDJ, 3FQN, 5HGD, 4K7F, 3RL2, 2GUO, 2P5E, 1B0R, 5TEZ, 5NMG, 3I6L, 3GSU, 5MEN, 3REW, 3MRN, 3MRF, 3QDM, 4NQV, 7L1B, 5N6B, 5F7D, 6ID4, 8D9V, 1DUZ, 7RRG, 4QOK, 3V5K, 4L3C, 5FA4, 8D4C, 1S9X, 5NQK, 3GSW, 5GRG, 3H9S, 5EU3, 5C07, 5F9J, 3BHB, 2VLL, 3QDG, 7L1D, 4NO0, 2F54, 6SS7, 3MRH, 1HSB, 3WL9, 7UC5, 1T21, 1OGA, 6EI2, 2X70, 7L1C, 5MER, 8D9W, 1QVO, 6PTB, 3PWJ, 5C0E, 6O9B, 4MJ6, 1B0G, 3GSV, 1I4F, 1TVB, 2GT9, 8D9T, 1I1Y, 3O4L, 3GIV, 3GJF, 3VXM, 8DVG, 5ENW, 3V5D, 4WUU, 1I7U, 5EU5, 6OPD, 1S9Y, 4F7M, 5GRD, 8D4E, 3HPJ, 4HX1, 6SSA, 6EWC, 3GSQ, 3BH9, 2X4O, 4I4W, 2VLK, 4NO5, 3TO2, 3BGM, 2X4S, 1QR1, 5SWQ, 5NMF, 1S8D, 5D2L, 4MNQ, 4NNY, 1T1Z, 5C0B, 6JOZ, 3FQU, 5MEO, 6R2L, 3MRG, 1HHK, 5C0F, 1JF1, 4FTV, 1S9W, 6G3J, 4UQ2, 3D25, 5C09, 3UTQ, 2GJ6, 4E5X, 4GKS, 2VLR, 2V2W, 5E6I, 3W0W, 5XOV, 3FQW, 3FQR, 6SS9, 4NO3, 2CLR, 3H7B, 3MRQ, 5HHM, 6EWO, 6RPB, 3MR9, 3FT2, 3MRC, 3MRK, 3KLA, 1HHH, 3IXA, 6ENY, 6RP9, 5WKF, 6J29, 7RK7, 5HGA, 1HLA, 5JZI, 8D9R, 5D2N, 5NMH, 5C0D, 1QSF, 3VXO, 5WWU, 6DKP, 1P7Q, 3UTT, 6G3K, 1I7T, 6Q3S, 6Q3K, 1AQD, 4GKN, 4OV5, 5WXD, 1I1F, 1QRN, 4JFQ, 2F53, 3GSR, 3O3B, 4NO2, 6EQA, 4WJ5, 6EWA, 5D9S, 3MRI, 5HHN, 1T20, 3QEQ, 3MRP, 2X4P, 3MGT, 3GSN, 1IM3, 4EMZ, 2GTW, 5MEQ, 6PTE, 5NME, 1EEZ, 3MRJ, 3MRB, 5C0J, 1T1Y, 5WJL, 5ISZ, 1HHJ, 3PWN, 4U6X, 6PBH, 5C0I, 3UTS, 5E00, 3VXN, 2BCK, 4WU5, 5JHD, 5C0A, 6NCA, 5WSH, 5WWI, 4L3E, 4NQX, 2AV1, 2C7U, 6SS8, 6AMT, 1W72, 4HWZ, 3I6K, 7RM4, 2X4R, 7MLE, 4I48, 3QZW, 3RL1, 1AO7, 3MRE, 3MRM, 1LP9, 5HHO, 4NNX, 5BRZ, 2J8U, 3PWL, 1T1W, 3FQT, 3O3E, 3BH8, 2X4U, 6J1W, 5C0G, 4L29, 5NMK, 5EUO, 5GSD, 5YXN, 1QSE, 3HAE, 4UQ3, 5EOT, 1I7R, 1JHT, 5C08, 2GIT, 3V5H, 5WWJ, 8D4F, 4F7T, 5BS0, 2V2X, 3GSX, 6AMU, 2HN7, 5IRO, 4JFD, 1X7Q, 3WLB, 2X4Q, 4EUP, 1TVH, 2X4T, 5WKH, 3MRD, 3MRL, 2BNR, 1EEY, 1AKJ, 5HHP, 6J2A, 3MRR, 8D9U, 4EN2, 1HHG, 4JFE, 3O3D, 1T1X, 4JFO, 3FT3, 5HGB, 4U6Y, 2XPG, 3PWP, 6EQB, 3D3V, 3VXP, 5FA3, 1HHI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.77	10
UniProt:P34925 RYK	1	RYK [plasma membrane] (R-HSA-3006746)	0.569	3
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.527	2
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.527	2

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