Transport of MHC heterotrimer to ER exit site

Stable Identifier
Reaction [dissociation]
Homo sapiens
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When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.

Literature References
PubMed ID Title Journal Year
19342655 Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum

Edidin, M, Van Prooyen, N, Ladasky, JJ, Abe, F

J Immunol 2009
14718384 Quality control of MHC class I maturation

Paulsson, KM, Wang, P

FASEB J 2004
17056546 Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules

Seth, M, Edidin, M, Li, H, Boyle, S, Pentcheva, T, Abe, F, Ladasky, JJ, Steinberg, SJ

J Immunol 2006
11163199 Selective export of MHC class I molecules from the ER after their dissociation from TAP

Manley, H, Spiliotis, ET, Edidin, M, Zúñiga, MC, Osorio, M

Immunity 2000
Orthologous Events
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