Reactome | Polyubiquitination of substrate

Polyubiquitination of substrate

Stable Identifier

R-HSA-983156

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12646216	U-box proteins as a new family of ubiquitin ligases Hatakeyama, S, Nakayama, KI	Biochem Biophys Res Commun	2003
16954532	A novel family of membrane-bound E3 ubiquitin ligases Goto, E, Hotta, H, Ishido, S, Mito, M, Uematsu, M, Aoki, M, Ohmura-Hoshino, M, Matsuki, Y	J Biochem	2006
19489725	RING domain E3 ubiquitin ligases Deshaies, RJ, Joazeiro, CA	Annu Rev Biochem	2009
19874575	Mechanisms of ubiquitin transfer by the anaphase-promoting complex Rodrigo-Brenni, MC, Matyskiela, ME, Morgan, DO	J Biol	2009