Class I MHC mediated antigen processing & presentation

Stable Identifier
R-HSA-983169
Type
Pathway
Species
Homo sapiens
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Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface.

Literature References
PubMed ID Title Journal Year
18926908 The quality control of MHC class I peptide loading

Cresswell, P, Wearsch, PA

Curr Opin Cell Biol 2008
17145306 Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

Ploegh, HL, Loureiro, J

Adv Immunol 2006
8717519 Antigen processing and presentation by the class I major histocompatibility complex

Rock, KL, York, IA

Annu Rev Immunol 1996
18641646 The known unknowns of antigen processing and presentation

Ploegh, HL, Van der Veen, AG, Vyas, JM

Nat Rev Immunol 2008
12495737 Assembly and export of MHC class I peptide ligands

Powis, SJ, Elliott, T, Antoniou, AN

Curr Opin Immunol 2003
18243674 Molecular machinations of the MHC-I peptide loading complex

Purcell, AW, Elliott, T

Curr Opin Immunol 2008
17055423 The complex route to MHC class I-peptide complexes

Neefjes, J, Elliott, T

Cell 2006
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Orthologous Events
Cross References
GlyCosmos
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