Reactome | Kinesin-1 is a heterotetramer

Kinesin-1 is a heterotetramer

Stable Identifier

R-HSA-983194

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Kinesin-1 is a heterotetramer of two heavy chains (HCs) and two light chains (LCs). The HC tail binds microtubules and inhibits ATPase activity by interacting with the enzymatic HC heads. LCs regulate the head and microtubule-binding activities of the HC tail by reducing the affinity of the head-tail interaction over tenfold. By a separate mechanism LCs inhibit microtubule binding.

Literature References

PubMed ID	Title	Journal	Year
3130248	The quaternary structure of bovine brain kinesin Vaisberg, EA, Chernyak, VY, Kuznetsov, SA, Magretova, NN, Shanina, NA, Gelfand, VI	EMBO J	1988
3134048	Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide Brady, ST, Pfister, KK, Wagner, MC, Bloom, GS	Biochemistry	1988
1607388	Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells Vale, RD, McCaffrey, G, Navone, F, Niclas, J, Sparks, L, Hom-Booher, N, Bernstein, HD	J Cell Biol	1992