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FURIN [trans-Golgi network membrane]
Stable Identifier
R-HSA-9832627
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Furin
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
F0 is cleaved, releasing F1, F2, F(110-136) (Homo sapiens)
Furin-type peptidase [trans-Golgi network membrane] (Homo sapiens)
FURIN [trans-Golgi network membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
1629222
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage
Leduc, R
,
Molloy, S S
,
Thorne, BA
,
Thomas, G
J Biol Chem
1992
External Reference Information
External Reference
UniProt:P09958 FURIN
Gene Names
FURIN, FUR, PACE, PCSK3
Chain
signal peptide:1-26, propeptide:27-107, chain:108-794
Reference Genes
BioGPS Gene:5045 FURIN
COSMIC (genes):FURIN FURIN
CTD Gene:5045 FURIN
dbSNP Gene:5045 FURIN
ENSEMBL:ENSG00000140564 FURIN
ENSEMBL_homo_sapiens_GENE:ENSG00000140564.13 FURIN
HGNC:8568 FURIN
KEGG Gene (Homo sapiens):5045 FURIN
Monarch:5045 FURIN
NCBI Gene:5045 FURIN
OMIM:136950 FURIN
UCSC:P09958 FURIN
Reference Transcript
RefSeq:NM_001289824.1 FURIN
RefSeq:NM_001289823.1 FURIN
RefSeq:NM_002569.3 FURIN
Other Identifiers
11716282_s_at
16804942
201945_PM_at
201945_at
35338_at
3608399
3608401
3608402
3608404
3608405
3608406
3608407
3608408
3608409
3608411
3608412
3608413
3608414
3608415
3608417
3608418
3608420
3608421
3608422
3608423
3608424
3608425
3608426
3608428
3608429
3608430
3608431
3608432
5045
7986092
A_23_P3368
GO:0000139
GO:0001825
GO:0002020
GO:0002376
GO:0002862
GO:0003824
GO:0004175
GO:0004252
GO:0004867
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005783
GO:0005794
GO:0005796
GO:0005802
GO:0005886
GO:0006465
GO:0006508
GO:0006954
GO:0007179
GO:0008201
GO:0008233
GO:0008236
GO:0009966
GO:0009986
GO:0010008
GO:0016020
GO:0016485
GO:0016486
GO:0016787
GO:0019058
GO:0019081
GO:0019082
GO:0022617
GO:0023052
GO:0030140
GO:0030163
GO:0030198
GO:0030574
GO:0031410
GO:0031638
GO:0032374
GO:0032804
GO:0032902
GO:0032911
GO:0032940
GO:0034369
GO:0042176
GO:0042277
GO:0043043
GO:0043226
GO:0045121
GO:0046598
GO:0046872
GO:0048406
GO:0048856
GO:0051044
GO:0051604
GO:0052548
GO:0070062
GO:0090472
GO:0098772
GO:0140096
GO:0140447
GO:1904399
GO:1990000
HMNXSV003039920
ILMN_1790228
PH_hs_0003807
TC15000870.hg
TC15002368.hg
X17094_at
g4505578_3p_at
Participates
as a candidate of
Furin-type peptidase [trans-Golgi network membrane] (Homo sapiens)
Other forms of this molecule
FURIN [macropinosome membrane]
FURIN [Golgi lumen]
FURIN [plasma membrane]
FURIN [extracellular region]
FURIN [Golgi membrane]
Cross References
RefSeq
NP_001276752.1
,
NP_002560.1
,
NP_001276753.1
Guide to Pharmacology - Targets
2366
OpenTargets
ENSG00000140564
ZINC - Substances
FURIN_HUMAN
ZINC target
P09958
PRO
P09958
PDB
8B4X
,
6EQW
,
6HZA
,
8OYH
,
8B4W
,
5JXJ
,
5MIM
,
5JXI
,
7QY2
,
7O1U
,
6HLD
,
6YD7
,
6HZB
,
7O22
,
6YD2
,
7O20
,
6HLE
,
7O1W
,
6EQX
,
7QXY
,
6A8Y
,
6HZC
,
6YD3
,
4OMC
,
5JMO
,
7O1Y
,
4OMD
,
7LCU
,
4RYD
,
8B4V
,
6EQV
,
5JXH
,
7QY1
,
5JXG
,
7QY0
,
6HZD
,
6HLB
,
4Z2A
,
6YD4
,
7QXZ
IntEnz
3.4.21.75
GeneCards
P09958
HPA
ENSG00000140564-FURIN
Ensembl
ENSP00000506143
,
ENSP00000483552
,
ENST00000268171
,
ENST00000610579
,
ENSP00000268171
,
ENSP00000484952
,
ENST00000680053
,
ENSG00000140564
,
ENST00000618099
Pharos - Targets
P09958
ZINC - Predictions - Purchasable
FURIN_HUMAN
HMDB Protein
HMDBP07695
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.854
5
UniProt:O14793 MSTN
1
MSTN [extracellular region]
(R-HSA-9625529)
0.623
2
UniProt:K9N5Q8 SPIKE
0.623
3
UniProt:P50281 MMP14
4
MMP14 [Golgi membrane]
(R-HSA-9858808)
MMP14(21-582) [Golgi lumen]
(R-HSA-1604689)
MMP14 [Golgi lumen]
(R-HSA-1604724)
MMP14 [plasma membrane]
(R-HSA-1442472)
0.564
3
UniProt:Q9H239 MMP28
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P55899 FCGRN
0.527
2
UniProt:P05154 SERPINA5
1
SERPINA5 [extracellular region]
(R-HSA-5591085)
0.527
2
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